Evidence map›Paper›PMID 28003287›Full record

ArticleBMJ open2016

Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific.

Holger W Unger, Jordan E Cates, Julie Gutman, Valerie Briand, Nadine Fievet, Innocent Valea, Halidou Tinto, Umberto d'Alessandro, Sarah H Landis, Seth Adu-Afarwuah and 22 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 18 institutions in 13 countries.

Holger W UngerDepartment of Obstetrics and Gynaecology, Edinburgh Royal Infirmary, Edinburgh, UK.
Jordan E CatesDepartment of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-4300-7416
Julie GutmanMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Valerie BriandInstitut de Recherche pour le Développement (IRD), Mère et enfant face aux infections tropicales (UMR216), Paris, France.
Nadine FievetInstitut de Recherche pour le Développement (IRD), Mère et enfant face aux infections tropicales (UMR216), Paris, France.
Innocent ValeaUnite de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé-DRO, Bobo-Dioulasso, Burkina Faso.
Halidou TintoUnite de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé-DRO, Bobo-Dioulasso, Burkina Faso.
Umberto d'AlessandroMedical Research Council Unit, The Gambia.
Sarah H LandisWorldwide Epidemiology, GlaxoSmithKline, Uxbridge, UK.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana.
Kathryn G DeweyDepartment of Nutrition, University of California, Davis, California, USA.
Feiko Ter KuileDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Stephanie DellicourDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Peter OumaKenya Medical Research Institute (KEMRI)/Center for Global Health Research, Kisumu, Kenya.
Laurence SlutskerMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Dianne J TerlouwMalawi-Liverpool-Wellcome Trust Clinical Research Programme Liverpool School of Tropical Medicine, Liverpool, UK.
Simon KariukiKenya Medical Research Institute (KEMRI)/Center for Global Health Research, Kisumu, Kenya.
John AyisiKenya Medical Research Institute (KEMRI)/Center for Global Health Research, Kisumu, Kenya.
Bernard NahlenPresident's Malaria Initiative, Washington DC, USA.
Meghna DesaiMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Mwayi MadanitsaSchool of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
Linda Kalilani-PhiriDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Per AshornTampere Center for Child Health Research, Tampere, Finland.
Kenneth MaletaSchool of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
Ivo MuellerWalter and Eliza Hall Institute, Parkville, Victoria, Australia.
Danielle StanisicInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.
Christentze SchmiegelowFaculty of Health Science, Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.
John LusinguFaculty of Health Science, Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.
Daniel WestreichDepartment of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA.
Anna Maria van EijkDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Steven MeshnickDepartment of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA.
Stephen RogersonDepartment of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia.
Centers for Disease Control and Prevention · USKenya Medical Research Institute · KELiverpool School of Tropical Medicine · GBUniversity of Malawi · MWUniversity of North Carolina at Chapel Hill · USCentre Muraz · BFDélégation Paris 5 · FRThe University of Melbourne · AUUniversity of Copenhagen · DKGlaxoSmithKline (United Kingdom) · GBGriffith University · AULondon School of Hygiene & Tropical Medicine · GBTampere University Hospital · FIUniversity of California, Davis · USUniversity of Ghana · GHUniversity of Liverpool · GBU.S. President's Malaria Initiative · USWalter and Eliza Hall Institute of Medical Research · AU

Funding

Training in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0M
Medical Research Council MC_UP_A900_1119NIAID NIH HHS T32 AI070114Wellcome Trust
6 · The paper itself

Abstract

purposeThe Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists.

participantsData were pooled on 14 635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015. FINDINGS TO DATE: Data are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort. FUTURE PLANS: This pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.

Indexed as

Fetal DevelopmentGestational AgeNutritional StatusPregnancy ComplicationsAdultAfricaCohort StudiesDatasets as TopicFemaleHumansInfant, NewbornMalariaMaleMalnutritionPapua New GuineaPregnancymalariamalnutritionpregnancy

Identifiers

PMID28003287
PMCPMC5223676
OpenAlexW2561037946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.