Evidence map›Paper›PMID 28003214›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.

Katelynn Faulk, Brent Shell, T Prashant Nedungadi, J Thomas Cunningham

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Spontaneous and evoked angiotensin II sniffer cell activity in the lamina terminalis in vitro.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  4. Chronic intermittent hypoxia-induced hypertension: the impact of sex hormones.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katelynn FaulkInstitute for Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas; and.
Brent ShellInstitute for Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas; and.
T Prashant NedungadiInstitute for Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas; and.
J Thomas CunninghamInstitute for Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas; and Tom.Cunningham@unthsc.edu.
University of North Texas · USUniversity of North Texas Health Science Center · US

Funding

Neurohumoral Adaptations to Chronic Intermittent Hypoxia: Insights into the Pathophysiology of Sleep ApneaP01HL088052 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI TONEY, GLENN M · 2008 to 2019
$18.8M
NHLBI NIH HHS P01 HL088052
6 · The paper itself

Abstract

Sustained hypertension is an important consequence of obstructive sleep apnea. An animal model of the hypoxemia associated with sleep apnea, chronic intermittent hypoxia (CIH), produces increased sympathetic nerve activity (SNA) and sustained increases in blood pressure. Many mechanisms have been implicated in the hypertension associated with CIH, including the role of ΔFosB within the median preoptic nucleus (MnPO). Also, the renin-angiotensin system (RAS) has been associated with CIH hypertension. We conducted experiments to determine the possible association of FosB/ΔFosB with a RAS component, angiotensin-converting enzyme 1 (ACE1), within the MnPO following 7 days of CIH. Retrograde tract tracing from the paraventricular nucleus (PVN), a downstream region of the MnPO, was used to establish a potential pathway for FosB/ΔFosB activation of MnPO ACE1 neurons. After CIH, ACE1 cells with FosB/ΔFosB expression increased colocalization with a retrograde tracer that was injected unilaterally within the PVN. Also, Western blot examination showed ACE1 protein expression increasing within the MnPO following CIH. Chromatin immunoprecipitation (ChIP) assays demonstrated an increase in FosB/ΔFosB association with the ACE1 gene within the MnPO following CIH. FosB/ΔFosB may transcriptionally target ACE1 within the MnPO following CIH to affect the downstream PVN region, which may influence SNA and blood pressure.

Indexed as

AnimalsHypoxiaMaleNeuronsPeptidyl-Dipeptidase APreoptic AreaProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyFosb protein, ratPeptidyl-Dipeptidase AProto-Oncogene Proteins c-fosangiotensinhypertensionmedian preoptic nucleussleep apnea

Identifiers

PMID28003214
PMCPMC5336571
OpenAlexW2566124452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.