ArticleCognitive neuroscience2017
Resting-state fMRI data reflects default network activity rather than null data: A defense of commonly employed methods to correct for multiple comparisons.
Article in Cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A randomized trial showing mnemonic strategy training increases memory, brain activation, and functional connectivity more than vanishing cue training in cognitively intact older adults.Neuropsychological rehabilitation · 2026Trial
- Effects of extended-release naltrexone on the brain response to drug-related stimuli in patients with opioid use disorder.Journal of psychiatry & neuroscience : JPN · 2018Trial
- Exergame as medicine? Functional brain adaptations linked to cognitive changes in neurocognitive disorders: exploratory randomized controlled trial.GeroScience · 2026Article
- A mediation approach in resting-state connectivity between the medial prefrontal cortex and anterior cingulate in mild cognitive impairment.Aging clinical and experimental research · 2024Article
- Left anterior supramarginal gyrus activity during tool use action observation after extensive tool use training.Experimental brain research · 2023Article
- Cortico-cerebellar audio-motor regions coordinate self and other in musical joint action.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Emotional salience but not valence impacts anterior cingulate cortex conflict processing.Cognitive, affective & behavioral neuroscience · 2022Article
- The Neural Bases of Egocentric Spatial Representation for Extracorporeal and Corporeal Tasks: An fMRI Study.Brain sciences · 2021Article
- Neuroplasticity in post-stroke aphasia: A systematic review and meta-analysis of functional imaging studies of reorganization of language processing.Neurobiology of language (Cambridge, Mass.) · 2021Article
- Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia.NeuroImage. Clinical · 2021Article
- Thalamic Functional Connectivity during Spatial Long-Term Memory and the Role of Sex.Brain sciences · 2020Article
- The Impact of Focused Attention on Emotional Experience: A Functional MRI Investigation.Cognitive, affective & behavioral neuroscience · 2020Article
- Evaluating Alternative Correction Methods for Multiple Comparison in Functional Neuroimaging Research.Brain sciences · 2019Article
- Cluster failure revisited: Impact of first level design and physiological noise on cluster false positive rates.Human brain mapping · 2019Article
- Aberrant Functional Network Connectivity as a Biomarker of Generalized Anxiety Disorder.Frontiers in human neuroscience · 2017Article
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
Analysis of functional magnetic resonance imaging (fMRI) data typically involves over one hundred thousand independent statistical tests; therefore, it is necessary to correct for multiple comparisons to control familywise error. In a recent paper, Eklund, Nichols, and Knutsson used resting-state fMRI data to evaluate commonly employed methods to correct for multiple comparisons and reported unacceptable rates of familywise error. Eklund et al.'s analysis was based on the assumption that resting-state fMRI data reflect null data; however, their 'null data' actually reflected default network activity that inflated familywise error. As such, Eklund et al.'s results provide no basis to question the validity of the thousands of published fMRI studies that have corrected for multiple comparisons or the commonly employed methods to correct for multiple comparisons.
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Registered trials
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