Evidence map›Paper›PMID 28002750›Full record

ArticleBiophysical journal2016

Local Turgor Pressure Reduction via Channel Clustering.

Jonah K Scher-Zagier, Anders E Carlsson

Abstract read
In one paragraph

Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  3. Article
  4. Review
  5. Membrane bending by actin polymerization.Current opinion in cell biology · 2018
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonah K Scher-ZagierDepartment of Physics, Washington University, Saint Louis, Missouri.
Anders E CarlssonDepartment of Physics, Washington University, Saint Louis, Missouri. Electronic address: aec@wustl.edu.

Funding

PROTEIN NETWORKS AND FORCE GENERATION IN YEAST ENDOCYTOSISR01GM107667 · NIGMS · WASHINGTON UNIVERSITY · PI CARLSSON, ANDERS E · 2014 to 2017
$1.2M
INTERDISCIPLINARY TRAINING IN MECHANOBIOLOGY FROM NM TO CMT32EB018266 · NIBIB · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2014 to 2018
$987k
NIBIB NIH HHS T32 EB018266NIGMS NIH HHS R01 GM107667
6 · The paper itself

Abstract

The primary drivers of yeast endocytosis are actin polymerization and curvature-generating proteins, such as clathrin and BAR domain proteins. Previous work has indicated that these factors may not be capable of generating the forces necessary to overcome turgor pressure. Thus local reduction of the turgor pressure, via localized accumulation or activation of solute channels, might facilitate endocytosis. The possible reduction in turgor pressure was calculated numerically, by solving the diffusion equation through a Legendre polynomial expansion. It was found that for a region of increased permeability having radius 45 nm, as few as 60 channels with a spacing of 10 nm could locally decrease the turgor pressure by 50%. We identified a key dimensionless parameter, p = P

Indexed as

EndocytosisPressureActinsCell MembraneElasticityModels, BiologicalProtein MultimerizationProtein Structure, QuaternaryActins

Identifiers

PMID28002750
PMCPMC5192740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.