ArticlePloS one2016
A Novel igf3 Gene in Common Carp (Cyprinus carpio): Evidence for Its Role in Regulating Gonadal Development.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 38 citations in OpenAlex.
- Effects of Different Light Spectra on Growth Performance, Body Coloration, and Pigmentation-Related Gene Expression in Koi Carp (Animals : an open access journal from MDPI · 2026Article
- Hepatic Transcriptomics Reveals Sexually Dimorphic Expression of IGF/IGFR Genes Underlying Growth Differences in Spinibarbus hollandi.Marine biotechnology (New York, N.Y.) · 2026Article
- Molecular Regulation of Growth in Aquaculture: From Genes to Sustainable Production.Life (Basel, Switzerland) · 2025Review
- Identification of Insulin-like Growth Factor (IGF) Family Genes in the Golden Pompano,International journal of molecular sciences · 2024Article
- Dietary Effects of Fermented Cottonseed Meal Substituting Fishmeal on the Growth, Biochemical Indexes, Antioxidant Capacity, and Muscle Quality of Juvenile Golden Pompano (Aquaculture nutrition · 2024Article
- The Expression Pattern of Insulin-Like Growth Factor Subtype 3 (igf3) in the Orange-Spotted GrouperInternational journal of molecular sciences · 2023Article
- Analysis of circRNA and miRNA expression profiles in IGF3-induced ovarian maturation in spotted scat (Frontiers in endocrinology · 2022Article
- Article
- Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research.Fish physiology and biochemistry · 2021Review
- Insulin-like growth factors 1 and 2 regulate gene expression and enzymatic activity ofHeliyon · 2020Article
- Long noncoding RNA and mRNA expression profiles following igf3 knockdown in common carp, Cyprinus carpio.Scientific data · 2019Article
- Molecular characterization and expression profiles of insulin-like growth factors in yellowtail kingfish (Seriola lalandi) during embryonic development.Fish physiology and biochemistry · 2019Article
- Follicle-Stimulating Hormone RegulatesFrontiers in endocrinology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the insulin-like growth factor 3 (igf3) gene was recently discovered in fish ovary, its function in the gonads has received much attention. In this study, we isolated two igf3 subtypes from common carp (Cyprinus carpio), which comprised full-length cDNA of 707 and 1153 nucleotides encoding 205 and 198 amino acids (aa), respectively. The Igf3 aa sequence had the highest gene homology of 72% with the corresponding sequence in zebrafish (Danio rerio). Phylogenetic tree construction revealed that the C. carpio igf3 gene was first clustered with D. rerio and then with other teleost species. Igf3 mRNA was widely expressed, with expression being highest in the gonads and blood. In the gonad development stage, igf3a mRNA expression was highest in the maturity and recession stage of the ovary, and decline phase of the testis, while igf3b was highest in the recession and fully mature periods of the ovaries and testes, respectively. Western blotting of testis protein samples showed two bands of approximately 21 kDa and 34 kDa corresponding to the calculated molecular mass of the two Igf3 subtypes; no signal was detected in the ovary. The Igf3 protein was localized in the ovary granulosa cells and testis spermatogonium and spermatids. 17β-Ethinylestradiol treatment increased both ovary and testis igf3 mRNA expression. These findings suggest that Igf3 may play an important role in C. carpio gonadal development.
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