ArticleNature2017
Reversible methylation of m
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In one paragraph
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 727 papers.
0numbers the graph read from it
0cells of the map it votes in
727citing papers in PubMed
48.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
727 citing papers in PubMed, 1,062 citations in OpenAlex.
- The role of RNA modifications in cancer translational control.RNA biology · 2026Review
- The role, regulatory mechanisms, and therapeutic implications of FTO in gastrointestinal cancer.Genes & diseases · 2026Review
- Molecular functions, cellular responses and pathological implications of the RNA modification NNature reviews. Molecular cell biology · 2026Review
- It takes two to tango: the intersection of deubiquitinases and mMolecular cancer · 2026Review
- Site-specific inhibition of translation initiation via 2'-O-methylation.Nucleic acids research · 2026Article
- RNA Demethylase FTO Uses Conserved Aromatic Residues to Recognize the mRNA 5' Cap and Promote Efficient mThe Journal of biological chemistry · 2026Article
- Engineering mRNA-LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases.Exploration (Beijing, China) · 2026Review
- An ALKBH3 Inhibitor HUHS199 Suppresses Proliferation of Glioblastoma Cells by Targeting 1-Methyladenosine on GADD45A mRNA.Chemical biology & drug design · 2026Article
- RNA modifications as determinants of cancer cell death: from epitranscriptomic mechanisms to therapeutic targeting.Functional & integrative genomics · 2026Review
- mNature reviews. Neuroscience · 2026Review
- Blocking the mNature communications · 2026Article
- FTO in Bone Diseases: Functions, Mechanisms and Therapeutic Potential.Biomolecules · 2026Review
- mInsects · 2026Review
- Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity.Nucleic acids research · 2026Article
- N6-methyladenosine modification in the context of viral infection: from molecular mechanism to therapeutic potential.Virus research · 2026Review
- Exercise, Demethylase FTO, Neurological Disorders, and Neuropathic Pain: Potential Molecular Mechanisms.CNS neuroscience & therapeutics · 2026Review
- Engineering Bisubstrates to Target mChemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- The relevance of mJournal of cancer research and clinical oncology · 2026Review
- The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and Atherosclerosis.Biomolecules · 2026Review
- The Role of NMedComm · 2026Review
667 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Jan MauerDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Xiaobing LuoDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA.
Alexandre BlanjoieDepartment of Chemistry, IBMM UMR 5247, CNRS, Université de Montpellier ENSCM, UM Campus Triolet, Place E. Bataillon, 34095 Montpellier Cedex 05, France.
Xinfu JiaoDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA.
Anya V GrozhikDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Deepak P PatilDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Bastian LinderDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Brian F PickeringDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Jean-Jacques VasseurDepartment of Chemistry, IBMM UMR 5247, CNRS, Université de Montpellier ENSCM, UM Campus Triolet, Place E. Bataillon, 34095 Montpellier Cedex 05, France.
Qiuying ChenDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Steven S GrossDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Olivier ElementoDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Françoise DebartDepartment of Chemistry, IBMM UMR 5247, CNRS, Université de Montpellier ENSCM, UM Campus Triolet, Place E. Bataillon, 34095 Montpellier Cedex 05, France.
Megerditch KiledjianDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA.
Samie R JaffreyDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.
Cornell University · USInstitut des Biomolécules Max Mousseron · FRRutgers, The State University of New Jersey · US
Funding
Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0MRisk Genes and Environment Interactions in NTDsP01HD067244 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSS, MARGARET ELIZABETH · 2011 to 2020
$12.6MCANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1MMechanisms of epitranscriptomic regulation in cancerR01CA186702 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY, Michael Kharas · 2014 to 2026
$8.0MRegulation of Mammalian mRNA DecayR01GM067005 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI KILEDJIAN, MEGERDITCH · 2004 to 2022
$5.5MDiabetic Vasculopathy and Mitochondrial eNOSR37HL087062 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GROSS, STEVEN S · 2007 to 2016
$4.2MTraining Program in Developmental BiologyT32HD060600 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BAO, ZHIRONG, STUHLMANN, HEIDI · 2010 to 2024
$3.5MmRNA methylation: A novel mechanism that blocks signaling by drugs of abuseR01DA037150 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAFFREY, SAMIE R · 2013 to 2016
$1.5MPathways controlling mRNA translation pathways in dopaminergic neuronsR01DA037755 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAFFREY, SAMIE R · 2014 to 2018
$1.1MNCATS NIH HHS UL1 TR000457NCI NIH HHS R01 CA186702NCI NIH HHS T32 CA062948NHLBI NIH HHS R37 HL087062NICHD NIH HHS P01 HD067244NICHD NIH HHS T32 HD060600NIDA NIH HHS R01 DA037150NIDA NIH HHS R01 DA037755NIGMS NIH HHS R01 GM067005
Abstract
Internal bases in mRNA can be subjected to modifications that influence the fate of mRNA in cells. One of the most prevalent modified bases is found at the 5' end of mRNA, at the first encoded nucleotide adjacent to the 7-methylguanosine cap. Here we show that this nucleotide, N
Indexed as
RNA StabilityAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsEndoribonucleasesEpigenesis, GeneticGuanosineHalf-LifeHEK293 CellsHumansMaleMethylationMiceMicroRNAsRNA CapsSubstrate Specificity7-methylguanosineAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOEndoribonucleasesFTO protein, humanGuanosineMicroRNAsmRNA decapping enzymesN(6),O(2)-dimethyladenosineN-methyladenosineRNA Caps
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.