ArticleAIDS (London, England)2017
Use of visual inspection with acetic acid, Pap smear, or high-risk human papillomavirus testing in women living with HIV/AIDS for posttreatment cervical cancer screening: same tests, different priorities.
Article in AIDS (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Residual or Recurrent Precancerous Lesions After Treatment of Cervical Lesions in Human Immunodeficiency Virus-infected Women: A Systematic Review and Meta-analysis of Treatment Failure.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Pooled it
- Article
- Impact of telephone reminders on posttreatment follow-up among women treated for cervical precancers in Cameroon: A randomized controlled trial.Gynecologic oncology reports · 2025Article
- Prevalence and determinants of cervical cancer screening among women aged 15-49 years in Tanzania: analysis of demographic and health survey 2022.Archives of public health = Archives belges de sante publique · 2025Article
- Perceptions of barriers and facilitators for cervical cancer screening from women and healthcare workers in Ghana: Applying the Dynamic Sustainability Framework.PLOS global public health · 2025Article
- [Validity of visual inspection with acetic acid versus cervical cytology].Revista medica del Instituto Mexicano del Seguro Social · 2024Observational
- Factors associated with adherence to post-treatment follow-up among a cohort of women with acetic acid/Lugol's iodine positive lesions of the cervix in Cameroon: A retrospective cohort study.Gynecologic oncology reports · 2023Article
- The East Africa Consortium for human papillomavirus and cervical cancer in women living with HIV/AIDS.Annals of medicine · 2022Review
- Cervical Cancer Screening Cascade for women living with HIV: a cohort study from Zimbabwe.PLOS global public health · 2022Article
- Screening test accuracy to improve detection of precancerous lesions of the cervix in women living with HIV: a study protocol.BMJ open · 2020Article
- Novel concepts in cervical cancer screening: a comparison of VIA, HPV DNA test and p16Infectious agents and cancer · 2020Article
- Atypical cervical cytomorphologic predictors: a descriptive study of pre-cervical cancer patients of low education in Kenya.The Pan African medical journal · 2019Article
- Cost-Effectiveness of Cervical Cancer Screening in Women Living With HIV in South Africa: A Mathematical Modeling Study.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Prevalence, risk factors, and pregnancy outcomes of cervical cell abnormalities in the puerperium in a hyperendemic HIV setting.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2018Article
- Self- versus physician-collected samples for the follow-up of human papillomavirus-positive women in sub-Saharan Africa.International journal of women's health · 2018Article
- Efficacy of thermoablation in treating cervical precancerous lesions in a low-resource setting.International journal of women's health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesFew studies have addressed optimal follow-up for HIV-infected women after cervical treatment. This study aimed to compare performance of three available tests to detect posttreatment cervical disease in HIV-infected women in Kenya.
designThis is a prospective cohort study.
methodsAt least 6 months following cryotherapy, 517 HIV-infected women were evaluated concurrently with visual inspection with acetic acid (VIA), papanicolaou (Pap) smear, and high-risk human papillomavirus (HR-HPV) testing. Women positive by any test (≥low-grade squamous intraepithelial lesion for Pap) were scheduled for colposcopy and biopsy. Among 248 with histological confirmation [and 174 assumed to be truly negative for cervical intraepithelial neoplasia (CIN)2+ after testing negative by all three tests], the ability of each test alone, or in combination, to detect CIN2+ was calculated to determine their utility in posttreatment follow-up.
resultsThe median age of women was 35 years, 68% were WHO stage 1-2, with a median CD4 cell count of 410 cells/μl, and 87% were on combination antiretroviral therapy. At a median of 6.3 months posttreatment, 64% had an abnormal screen by VIA, Pap, and/or HR-HPV. Among women with histological confirmation, 72 (30%) had persistent/recurrent CIN2+. As single tests, Pap correctly classified the most cases (83%) and had the highest specificity [91% (88 and 95%); sensitivity 44% (35 and 53%)], whereas HR-HPV had the highest sensitivity [85% (75 and 96%); specificity 54% (49 and 58%)]. VIA was not sensitive [27% (18 and 36%)] for the detection of posttreatment CIN2+ [specificity 82% (79 and 86%)].
conclusionWith the goal to minimize the number of false negatives (e.g. not miss CIN2+ posttreatment) in this population that is high-risk due to both prior cervical disease and HIV infection, HR-HPV-based algorithms are recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.