ArticlePhysics in medicine and biology2017
In vitro thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator and octafluoropropane gas.
Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Assessment of Cavitation From DEFINITY and DEFINITY RT.Ultrasound in medicine & biology · 2026Article
- Optimized TELIP, an Echogenic Liposomal Nano-Carrier Loaded with Alteplase for Preclinical Studies.Pharmaceutics · 2026Article
- Sonoporation with Echogenic Liposomes: The Evaluation of Glioblastoma Applicability Using In Vivo Xenograft Models.Pharmaceutics · 2025Article
- Innovations in Breaking Barriers: Liposomes as Near-Perfect Drug Carriers in Ischemic Stroke Therapy.International journal of nanomedicine · 2024Review
- Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter.Scientific reports · 2023Article
- Assessment of bubble activity generated by histotripsy combined with echogenic liposomes.Physics in medicine and biology · 2022Article
- Synthetic cells in biomedical applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Recent Advances in Nanomaterials for Diagnosis, Treatments, and Neurorestoration in Ischemic Stroke.Frontiers in cellular neuroscience · 2022Review
- Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke.Drug delivery · 2021Article
- New Approaches in Nanomedicine for Ischemic Stroke.Pharmaceutics · 2021Review
- Examining the Influence of Low-Dose Tissue Plasminogen Activator on Microbubble-Mediated Forward-Viewing Intravascular Sonothrombolysis.Ultrasound in medicine & biology · 2020Article
- Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.Ultrasound in medicine & biology · 2020Review
- Nano-Medicine for Thrombosis: A Precise Diagnosis and Treatment Strategy.Nano-micro letters · 2020Review
- Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers.Sensors (Basel, Switzerland) · 2020Review
- The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.Physics in medicine and biology · 2019Article
- In vitro characterization of sonothrombolysis and echocontrast agents to treat ischemic stroke.Scientific reports · 2019Article
- Recent strategies on targeted delivery of thrombolytics.Asian journal of pharmaceutical sciences · 2019Review
- An in vitro proof-of-principle study of sonobactericide.Scientific reports · 2018Article
- Effect of Temperature on the Size Distribution, Shell Properties, and Stability of DefinityUltrasound in medicine & biology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Echogenic liposomes loaded with the thrombolytic recombinant tissue-type plasminogen activator (rt-PA) are under development for the treatment of ischemic stroke. These agents are designed to co-encapsulate cavitation nuclei to promote bubble activity in response to ultrasound exposure, and to enable localized delivery of thrombolytic. Stable cavitation improves the efficacy of the thrombolytic through enhanced fluid mixing. Echogenic liposomes that encapsulate air-filled microbubbles nucleate scant stable cavitation activity in response to 120 kHz intermittent ultrasound exposure, and have demonstrated thrombolytic efficacy equivalent to rt-PA alone. It was hypothesized that encapsulating octafluoropropane (OFP) gas within rt-PA-loaded liposomes instead of air will enhance ultrasound-mediated stable cavitation activity and increase thrombolytic efficacy compared to previous studies. The thrombolytic efficacy and cavitation activity nucleated from liposomes that encapsulate OFP microbubbles and rt-PA (OFP t-ELIP) was evaluated in vitro. Human whole blood clots were exposed to human fresh-frozen plasma alone, rt-PA (0, 0.32, 1.58, and 3.15 µg ml
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.