Evidence map›Paper›PMID 28001376›Full record

ArticleChemical research in toxicology2017

Thirdhand Smoke: New Evidence, Challenges, and Future Directions.

Peyton Jacob, Neal L Benowitz, Hugo Destaillats, Lara Gundel, Bo Hang, Manuela Martins-Green, Georg E Matt, Penelope J E Quintana, Jonathan M Samet, Suzaynn F Schick and 5 more

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 2 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 2 syntheses or guidelines pooled it, 256 citations in OpenAlex.

  1. Pooled it
  2. Analysis of Assessment Methods for Detecting Nicotine Residue and Its Impact on Humans: A Systematic Review.International journal of environmental research and public health · 2025
    Pooled it
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  14. On the Detection and Scope of "Third-Hand Vaping": A Critical Review of the Literature.International journal of environmental research and public health · 2026
    Review
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Peyton JacobDivision of Clinical Pharmacology and Experimental Therapeutics, Departments of Psychiatry and Medicine, University of California , San Francisco, California 94143, United States.ORCID 0000-0003-3366-2775
Neal L BenowitzDivision of Clinical Pharmacology and Experimental Therapeutics, Medical Service, Departments of Medicine, and Bioengineering & Therapeutic Sciences, University of California , San Francisco, California 94143, United States.
Hugo DestaillatsIndoor Environment Group, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
Lara GundelIndoor Environment Group, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
Bo HangBiological Systems & Engineering, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
Manuela Martins-GreenDepartment of Cell Biology and Neuroscience, University of California Riverside 92521, United States.
Georg E MattDepartment of Psychology, San Diego State University , San Diego, California 92182, United States.
Penelope J E QuintanaGraduate School of Public Health, San Diego State University , San Diego, California 92182, United States.
Jonathan M SametDepartment of Preventive Medicine, The Keck School of Medicine, University of Southern California , Los Angeles, California 90089, United States.
Suzaynn F SchickDivision of Occupational and Environmental Medicine, School of Medicine, University of California , San Francisco, California 94143, United States.
Prue TalbotDepartment of Cell Biology and Neuroscience, University of California Riverside 92521, United States.
Noel J AquilinaDepartment of Geosciences, University of Malta , Msida, MSD 2080, Malta.
Melbourne F HovellGraduate School of Public Health, San Diego State University , San Diego, California 92182, United States.
Jian-Hua MaoBiological Systems & Engineering, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
Todd P WhiteheadThe Center for Integrative Research on Childhood Leukemia and the Environment, School of Public Health, University of California , Berkeley, 94704, United States.
Lawrence Berkeley National Laboratory · USSan Diego State University · USUniversity of California, San Francisco · USUniversity of California, Riverside · USUniversity of California, Berkeley · USUniversity of Malta · MTUniversity of Southern California · US

Funding

Research Support CoreP30DA012393 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON · 1999 to 2024
$17.1M
Liquid Chromatograph-Triple Quadrupole Mass SpectrometerS10RR026437 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON · 2010 to 2010
$448k
NCRR NIH HHS S10 RR026437NIDA NIH HHS P30 DA012393
6 · The paper itself

Abstract

Thirdhand smoke (THS) is the contamination that persists after secondhand tobacco smoke has been emitted into air. It refers to the tobacco-related gases and particles that become embedded in materials, such as the carpet, walls, furniture, blankets, and toys. THS is not strictly smoke, but chemicals that adhere to surfaces from which they can be released back into the air, undergo chemical transformations and/or accumulate. Currently, the hazards of THS are not as well documented as the hazards of secondhand smoke (SHS). In this Perspective, we describe the distribution and chemical changes that occur as SHS is transformed into THS, studies of environmental contamination by THS, human exposure studies, toxicology studies using animal models and in vitro systems, possible approaches for avoiding exposure, remediation of THS contamination, and priorities for further research.

Indexed as

SmokeAir Pollution, IndoorAnimalsEnvironmental ExposureHumansParticulate MatterParticulate MatterSmoke

Identifiers

PMID28001376
PMCPMC5501723
OpenAlexW2557489566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.