Evidence map›Paper›PMID 28001098›Full record

ArticleHypertension in pregnancy2017

Pre-eclampsia and risk of subsequent hypertension: in an American Indian population.

Lyle G Best, Laramie Lunday, Elisha Webster, Gilbert R Falcon, James R Beal

Open access · hybridAbstract read
In one paragraph

Article in Hypertension in pregnancy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Maternal Weight Variation in Different Intrauterine Environments: An Important Role of Hypertension.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019
    Observational
  7. Article
  8. The Complement System and Preeclampsia.Current hypertension reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lyle G Besta Turtle Mountain Community College , Natural Science Department , Belcourt , North Dakota , USA.
Laramie Lundayb University of North Dakota, School of Medicine , Family and Community Medicine Department , Grand Forks , North Dakota , USA.
Elisha Websterb University of North Dakota, School of Medicine , Family and Community Medicine Department , Grand Forks , North Dakota , USA.
Gilbert R Falconb University of North Dakota, School of Medicine , Family and Community Medicine Department , Grand Forks , North Dakota , USA.
James R Bealb University of North Dakota, School of Medicine , Family and Community Medicine Department , Grand Forks , North Dakota , USA.
University of North Dakota · USTurtle Mountain Community College · US

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Chris Jurgens · 2012 to 2026
$53.0M
NIGMS NIH HHS P20 GM103442
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPre-eclampsia (PE) shares a number of proposed pathophysiologic mechanisms related to those implicated in cardiovascular disease (CVD), such as endothelial dysfunction, inflammation, insulin resistance, and impaired renal regulation. PE has also been associated with subsequent hypertension, CVD, and related mortality in later life.

methodsAt follow-up, the four most recent blood pressures, body mass index (BMI), and use of hypertensive medications were recorded from clinic visits of 130 PE cases and 289 normal pregnancies. Student's t test, Chi-square testing, multivariate linear, and logistic regression were used in analysis.

resultsFollow-up measurements occurred a mean of 13.11 years post PE pregnancy. Multivariate linear regression showed a significant and independent association between current systolic blood pressure and previous history of PE (β = 4.47, p = 0.04), while adjusting for age, BMI, and blood pressure from 1 year prior to and up to the 20th week of gestation. A similarly adjusted multivariate logistic regression model found an odds ratio of 3.43, 95% CI 1.83-6.43, p = 0.001 for subsequent hypertension. Logistic regression analysis of the quartile with follow-up of less than 7.19 years also shows independent association of prior PE with subsequent hypertension. DISCUSSION AND

conclusionsPE appears to confer risk of subsequent hypertension on this cohort of American Indian women within as little as 8 years. This risk is independent of additional risk factors such as increased age, BMI, and blood pressure prior to 20 weeks of gestation. There is evidence of increased risk among those with more severe PE.

Indexed as

AdolescentAdultFemaleFollow-Up StudiesHumansHypertensionIndians, North AmericanMiddle AgedNorth DakotaPre-EclampsiaPregnancyRetrospective StudiesYoung AdultCase–control studyhypertensionmultivariable analysispreeclampsia

Identifiers

PMID28001098
PMCPMC6097877
OpenAlexW2561251984

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.