Evidence map›Paper›PMID 28000997›Full record

ArticleAngewandte Chemie (International ed. in English)2017

In-Cell Activation of Organo-Osmium(II) Anticancer Complexes.

Russell J Needham, Carlos Sanchez-Cano, Xin Zhang, Isolda Romero-Canelón, Abraha Habtemariam, Margaret S Cooper, Levente Meszaros, Guy J Clarkson, Philip J Blower, Peter J Sadler

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Recent Advances in Anticancer Research of Osmium and Rhodium Complexes.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
  4. Review
  5. Cancer 3D Models for Metallodrug Preclinical Testing.International journal of molecular sciences · 2023
    Review
  6. Taming glutathione potentiates metallodrug action.Current opinion in chemical biology · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. NMR studies of group 8 metallodrugs:Dalton transactions (Cambridge, England : 2003) · 2021
    Article
  11. Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Russell J NeedhamDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0001-9801-2808
Carlos Sanchez-CanoDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0002-9522-0019
Xin ZhangDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0002-6366-9890
Isolda Romero-CanelónDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0003-3847-4626
Abraha HabtemariamDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0003-2128-800X
Margaret S CooperDivision of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas Hospital, London, SE1 7EH, UK.ORCID 0000-0001-9103-6639
Levente MeszarosDivision of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas Hospital, London, SE1 7EH, UK.ORCID 0000-0002-4698-0943
Guy J ClarksonDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0003-3076-3191
Philip J BlowerDivision of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas Hospital, London, SE1 7EH, UK.ORCID 0000-0001-6290-1590
Peter J SadlerDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0001-9160-1941
University of Warwick · GBSt Thomas' Hospital · GB

Funding

Cancer Research UK 16463Medical Research Council G0701062Wellcome TrustWellcome Trust 107691/Z/15/ZWellcome Trust WT088641/Z/09/Z
6 · The paper itself

Abstract

The family of iodido Os

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationDose Fractionation, RadiationDrug Screening Assays, AntitumorHumansMCF-7 CellsModels, MolecularMolecular ConformationOrganometallic CompoundsOsmiumStructure-Activity RelationshipAntineoplastic AgentsOrganometallic CompoundsOsmiumanticancer agentsbioinorganic chemistryglutathionemetallodrugsorgano-osmium complexes

Identifiers

PMID28000997
PMCPMC5412917
OpenAlexW2561303760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.