ArticleMolecular medicine reports2017
Fas expression is downregulated in gastric cancer.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Exploring the Role of Probiotics in the Prevention and Treatment of Gastrointestinal Cancer.Probiotics and antimicrobial proteins · 2026Review
- Quercetin selectively targets gingival squamous cell carcinoma through apoptosis induction, autophagy suppression, DNA damage, and chemosensitization.Frontiers in oncology · 2026Article
- Pyroptosis in cancer therapy: a double-edged sword for immune activation and tumor progression.Molecular cancer · 2025Review
- The anticancer potential of Origanum onites L. in gastric cancer through epigenetic alterations.BMC complementary medicine and therapies · 2025Article
- Role of ADP ribosylation factor guanylate kinase 1 in the malignant biological behavior of gastric cancer.Heliyon · 2024Article
- Fas cell surface death receptor/Fas ligand genetic variants in gastric cancer patients: A case-control study.The Indian journal of medical research · 2022Article
- The mechanisms on evasion of anti-tumor immune responses in gastric cancer.Frontiers in oncology · 2022Review
- Article
- Eleven immune-gene pairs signature associated with TP53 predicting the overall survival of gastric cancer: a retrospective analysis of large sample and multicenter from public database.Journal of translational medicine · 2021Article
- NUP210 and MicroRNA-22 Modulate Fas to Elicit HeLa Cell Cycle Arrest.Yonsei medical journal · 2020Article
- In silico analysis of the prognostic value of FAS mRNA in malignancies.Journal of Cancer · 2020Article
- Co-expression of caspase-3 or caspase-8 with galanin in the human stomach section affected by carcinoma.Apoptosis : an international journal on programmed cell death · 2018Article
- Prognostic significance of microsatellite instability‑associated pathways and genes in gastric cancer.International journal of molecular medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate Fas expression in tumor samples from patients with gastric cancer, in order to determine the involvement of the Fas signaling pathway. The protein expression levels of Fas, caspase-8, caspase‑3 and poly (adenosine diphosphate‑ribose) polymerase 1 (PARP1) were examined in gastric cancer specimens and their associations with clinical pathological parameters were analyzed with immunohistochemical staining and western blot analysis. The mRNA expression was quantified with quantitative PCR and apoptosis was examined with a FACScan flow cytometer. The results demonstrated that the downregulation of Fas expression was correlated with less histological differentiation, gender (male), and increased lymph node and distant metastases (P<0.05). In the AGS established gastric cancer cell line, upregulation of the Fas signaling pathway promoted the apoptosis of gastric cancer cells by upregulating the expression of caspase‑8 and caspase‑3, and downregulating the expression of PARP1. The present study demonstrated that Fas was associated with gastric cancer and promoted the apoptosis of gastric cancer cells via caspase‑8, caspase‑3 and PARP1. These results suggested that caspase‑8, caspase‑3 and PARP1 may be triggers of gastric cancer, and upregulation of caspase‑8 and caspase‑3 expression, or inhibition of PARP1 expression may improve the therapeutic outcome in patients with gastric cancer.
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