Evidence map›Paper›PMID 28000705›Full record

ArticleScientific reports2016

The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205

Kelly N S Amorim, Eline V Rampazo, Renan Antonialli, Marcio M Yamamoto, Mauricio M Rodrigues, Irene S Soares, Silvia B Boscardin

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Transboundary and emerging diseases · 2024
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  3. Recombinant antigen delivery to dendritic cells as a way to improve vaccine design.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
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  7. Review
  8. Protective Immunity in Mice Immunized WithFrontiers in immunology · 2020
    Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kelly N S AmorimLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, 05508-000, Brazil.
Eline V RampazoLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, 05508-000, Brazil.
Renan AntonialliLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, 05508-000, Brazil.
Marcio M YamamotoLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, 05508-000, Brazil.
Mauricio M RodriguesCTCMol, Federal University of São Paulo, São Paulo, 04044-010, Brazil.
Irene S SoaresNational Institute for Science and Technology in Vaccines, Belo Horizonte, 31270-910, Brazil.
Silvia B BoscardinLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, 05508-000, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo antigen targeting to dendritic cells (DCs) has been used as a way to improve immune responses. Targeting is accomplished with the use of monoclonal antibodies (mAbs) to receptors present on the DC surface fused with the antigen of interest. An anti-DEC205 mAb has been successfully used to target antigens to the DEC205

Indexed as

Amino Acid SequenceAnimalsAntibodies, MonoclonalAntibody FormationCD4 AntigensCD4-Positive T-LymphocytesCell ProliferationDendritic CellsEnzyme-Linked Immunosorbent AssayEpitopes, T-LymphocyteFemaleImmunoglobulin GInterferon-gammaInterleukin-2Lectins, C-TypeMerozoite Surface Protein 1Antibodies, MonoclonalCD4 AntigensEpitopes, T-LymphocyteImmunoglobulin GInterferon-gammaInterleukin-2Lectins, C-TypeMerozoite Surface Protein 1Recombinant Fusion ProteinsTumor Necrosis Factor-alpha

Identifiers

PMID28000705
PMCPMC5175286
OpenAlexW2567158539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.