Evidence map›Paper›PMID 28000623›Full record

ArticlePhysics in medicine and biology2017

Attenuation measuring ultrasound shearwave elastography and in vivo application in post-transplant liver patients.

Ivan Z Nenadic, Bo Qiang, Matthew W Urban, Heng Zhao, William Sanchez, James F Greenleaf, Shigao Chen

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
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  6. Review
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  13. Full waveform inversion for arterial viscoelasticity.Physics in medicine and biology · 2023
    Article
  14. Review
  15. Review
  16. Article
  17. Power laws prevail in medical ultrasound.Physics in medicine and biology · 2022
    Review
  18. Article
  19. Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ivan Z NenadicDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
Bo QiangDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
Matthew W UrbanDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
Heng ZhaoSonavation Inc., Palm Beach Gardens, FL, USA.
William SanchezDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA.
James F GreenleafDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
Shigao ChenDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.

Funding

Multidimensional Heart Imaging With UltrasoundR01EB002167 · NIBIB · MAYO CLINIC ROCHESTER · PI GREENLEAF, JAMES FOWLER, PISLARU, CRISTINA · 2003 to 2014
$6.1M
Measurement of Renal Viscoelastic Properties with UltrasoundR01DK092255 · NIDDK · MAYO CLINIC ROCHESTER · PI URBAN, MATTHEW WILLIAM · 2012 to 2022
$5.2M
Virtual Biopsy with Ultrasound for Liver Fibrosis StagingR01DK082408 · NIDDK · MAYO CLINIC ROCHESTER · PI CHEN, SHIGAO · 2009 to 2013
$1.6M
Attenuation Measuring Ultrasound Shearwave Elastography (AMUSE) for Noninvasive Assessment of Acute Cellular Rejection in Post-transplant Liver PatientsR21EB022183 · NIBIB · MAYO CLINIC ROCHESTER · PI CHEN, SHIGAO, NENADIC, IVAN Z · 2016 to 2017
$437k
NIBIB NIH HHS R01 EB002167NIBIB NIH HHS R21 EB022183NIDDK NIH HHS R01 DK082408NIDDK NIH HHS R01 DK092255
6 · The paper itself

Abstract

Ultrasound and magnetic resonance elastography techniques are used to assess mechanical properties of soft tissues. Tissue stiffness is related to various pathologies such as fibrosis, loss of compliance, and cancer. One way to perform elastography is measuring shear wave velocity of propagating waves in tissue induced by intrinsic motion or an external source of vibration, and relating the shear wave velocity to tissue elasticity. All tissues are inherently viscoelastic and ignoring viscosity biases the velocity-based estimates of elasticity and ignores a potentially important parameter of tissue health. We present attenuation measuring ultrasound shearwave elastography (AMUSE), a technique that independently measures both shear wave velocity and attenuation in tissue and therefore allows characterization of viscoelasticity without using a rheological model. The theoretical basis for AMUSE is first derived and validated in finite element simulations. AMUSE is validated against the traditional methods for assessing shear wave velocity (phase gradient) and attenuation (amplitude decay) in tissue mimicking phantoms and excised tissue. The results agreed within one standard deviation. AMUSE was used to measure shear wave velocity and attenuation in 15 transplanted livers in patients with potential acute rejection, and the results were compared with the biopsy findings in a preliminary study. The comparison showed excellent agreement and suggests that AMUSE can be used to separate transplanted livers with acute rejection from livers with no rejection.

Indexed as

Phantoms, ImagingUltrasonographyAnimalsElasticity Imaging TechniquesGraft RejectionHumansLiver DiseasesLiver TransplantationSwineViscosity

Identifiers

PMID28000623
PMCPMC5505633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.