ArticleNMR in biomedicine2017
Microstructural models for diffusion MRI in breast cancer and surrounding stroma: an ex vivo study.
Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Prediction of Chemotherapy Response in Locally Advanced Breast Cancer Patients at Pre-Treatment Using CT Textural Features and Machine Learning: Comparison of Feature Selection Methods.Tomography (Ann Arbor, Mich.) · 2025Article
- Characteristics of T2* and anisotropy parameters in inguinal and epididymal adipose tissues after cold exposure in mice.Scientific reports · 2024Article
- Apriori prediction of chemotherapy response in locally advanced breast cancer patients using CT imaging and deep learning: transformer versus transfer learning.Frontiers in oncology · 2024Article
- Ex-vivo 1.5T MR Imaging versus CT in Estimating the Size of the Pathologically Invasive Component of Lung Adenocarcinoma Spectrum Lesions.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Article
- Multi-model sequential analysis of MRI data for microstructure prediction in heterogeneous tissue.Scientific reports · 2023Article
- Quantitative diffusion MRI of the abdomen and pelvis.Medical physics · 2022Article
- Clinical experience of tensor-valued diffusion encoding for microstructure imaging by diffusional variance decomposition in patients with breast cancer.Quantitative imaging in medicine and surgery · 2022Article
- CRAFT (Cerclage after full dilatation caesarean section): protocol of a mixed methods study investigating the role of previous in-labour caesarean section in preterm birth risk.BMC pregnancy and childbirth · 2020Article
- A multimodal computational pipeline for 3D histology of the human brain.Scientific reports · 2020Article
- Magnetic resonance imaging of mean cell size in human breast tumors.Magnetic resonance in medicine · 2020Article
- q-Space Imaging Yields a Higher Effect Gradient to Assess Cellularity than Conventional Diffusion-weighted Imaging Methods at 3.0 T: A Pilot Study with Freshly Excised Whole-Breast Tumors.Radiology. Imaging cancer · 2019Article
- VERDICT MRI validation in fresh and fixed prostate specimens using patient-specific moulds for histological and MR alignment.NMR in biomedicine · 2019Article
- Microstructure Characterization of Bone Metastases from Prostate Cancer with Diffusion MRI: Preliminary Findings.Frontiers in oncology · 2018Article
- Article
- The distribution of the apparent diffusion coefficient as an indicator of the response to chemotherapeutics in ovarian tumour xenografts.Scientific reports · 2017Article
- Microstructural models for diffusion MRI in breast cancer and surrounding stroma: an ex vivo study.NMR in biomedicine · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The diffusion signal in breast tissue has primarily been modelled using apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and diffusion tensor (DT) models, which may be too simplistic to describe the underlying tissue microstructure. Formalin-fixed breast cancer samples were scanned using a wide range of gradient strengths, durations, separations and orientations. A variety of one- and two-compartment models were tested to determine which best described the data. Models with restricted diffusion components and anisotropy were selected in most cancerous regions and there were no regions in which conventional ADC or DT models were selected. Maps of ADC generally related to cellularity on histology, but maps of parameters from more complex models suggest that both overall cell volume fraction and individual cell size can contribute to the diffusion signal, affecting the specificity of ADC to the tissue microstructure. The areas of coherence in diffusion anisotropy images were small, approximately 1 mm, but the orientation corresponded to stromal orientation patterns on histology.
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Registered trials
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