ArticlePsychophysiology2017
Demonstrating test-retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response.
Article in Psychophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Variability and effect sizes of intracranial current source density estimations during pain: Systematic review, experimental findings, and future perspectives.Human brain mapping · 2021Pooled it
- Electroencephalographic Biomarkers for Treatment Response Prediction in Major Depressive Illness: A Meta-Analysis.The American journal of psychiatry · 2019Pooled it
- Towards causal inference-based antidepressant selection with brain and blood biomarkers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial.Biological psychiatry · 2019Trial
- Stability of frontal alpha asymmetry in depressed patients during antidepressant treatment.NeuroImage. Clinical · 2019Trial
- Pretreatment Rostral Anterior Cingulate Cortex Theta Activity in Relation to Symptom Improvement in Depression: A Randomized Clinical Trial.JAMA psychiatry · 2018Trial
- A Novel Strategy to Identify Placebo Responders: Prediction Index of Clinical and Biological Markers in the EMBARC Trial.Psychotherapy and psychosomatics · 2018Trial
- Translating Decades of Neuroscience Research into Diagnostic and Treatment Biomarkers for ADHD.Advances in neurobiology · 2024Review
- The novel frontal alpha asymmetry factor and its association with depression, anxiety, and personality traits.Psychophysiology · 2022Article
- A systematic data-driven approach to analyze sensor-level EEG connectivity: Identifying robust phase-synchronized network components using surface Laplacian with spectral-spatial PCA.Psychophysiology · 2022Article
- Data-Driven EEG Theta and Alpha Components Are Associated with Subjective Experience during Resting State.Journal of personalized medicine · 2022Article
- Physiologically informed neuromodulation.Journal of the neurological sciences · 2022Article
- A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment.Frontiers in human neuroscience · 2022Article
- Elucidating age and sex-dependent association between frontal EEG asymmetry and depression: An application of multiple imputation in functional regression.Journal of the American Statistical Association · 2022Article
- Neural signatures of heterogeneity in risk-taking and strategic consistency.The European journal of neuroscience · 2021Article
- Resting posterior alpha power and adolescent major depressive disorder.Journal of psychiatric research · 2021Article
- Prediction of dispositional dialectical thinking from resting-state electroencephalography.Brain and behavior · 2021Article
- Major Depressive Disorder in Older Patients as an Inflammatory Disorder: Implications for the Pharmacological Management of Geriatric Depression.Drugs & aging · 2021Review
- Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment.PloS one · 2021Article
- Frontal theta and posterior alpha in resting EEG: A critical examination of convergent and discriminant validity.Psychophysiology · 2020Article
Corrections and comments
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Authors and funding
21 authors at 9 institutions in 1 country.
Funding
Abstract
Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about the joint reliability of these markers, and thus their clinical applicability. New standardized procedures were developed to improve the compatibility of data acquired with different EEG platforms, and used to examine test-retest reliability for the three electrophysiological measures selected for a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). Thirty-nine healthy controls across four clinical research sites were tested in two sessions separated by about 1 week. Resting EEG (eyes-open and eyes-closed conditions) was recorded and LDAEP measured using binaural tones (1000 Hz, 40 ms) at five intensities (60-100 dB SPL). Principal components analysis of current source density waveforms reduced volume conduction and provided reference-free measures of resting EEG alpha and N1 dipole activity to tones from auditory cortex. Low-resolution electromagnetic tomography (LORETA) extracted resting theta current density measures corresponding to rostral anterior cingulate (rACC), which has been implicated in treatment response. There were no significant differences in posterior alpha, N1 dipole, or rACC theta across sessions. Test-retest reliability was .84 for alpha, .87 for N1 dipole, and .70 for theta rACC current density. The demonstration of good-to-excellent reliability for these measures provides a template for future EEG/ERP studies from multiple testing sites, and an important step for evaluating them as biomarkers for predicting treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.