ReviewThe journal of physiological sciences : JPS2017
Pathology and molecular mechanisms of coarctation of the aorta and its association with the ductus arteriosus.
Review in The journal of physiological sciences : JPS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03262753 (LOVE-COARCT Study), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
LOVE-COARCT Study: Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Isolated Coarctation of the Aorta: Current Concepts and Perspectives.Frontiers in cardiovascular medicine · 2022Pooled it
- Balloon Angioplasty for Recoarctation in Infants with Isolated Aortic Coarctation and Coarctation Associated with Other Congenital Heart Diseases.Journal of cardiovascular development and disease · 2026Article
- An Experimental and Computational Investigation to Establish the Mechanical Behaviour of Paediatric Aortic Coarctation Tissue.Annals of biomedical engineering · 2026Article
- Developmental and Structural Alterations at the Ductus-Aortic Isthmus Interface in Infantile Coarctation of the Aorta: A Biological Basis for Persistent Vascular Disease Beyond Anatomical Repair.Journal of clinical medicine · 2026Article
- Severity and duration-dependent aortic stiffening in a rabbit coarctation model identifies constitutive material parameters as promising regional biomarkers for hypertension progression.Scientific reports · 2026Article
- End-to-End Resection for Neonatal Aortic Coarctation with Severe Left Ventricular Dysfunction and Large Ventricular Septal Defect: A Case Report in a 23-Day-Old Infant.International medical case reports journal · 2026Article
- Endovascular Repair of Thoracic Aortic Atresia in Adults: A Narrative Review of a Rare Entity and Emerging Technique.Life (Basel, Switzerland) · 2025Review
- Prenatal ultrasound prediction of coarctation of the aorta: a nomogram for risk stratification.Pediatric radiology · 2025Article
- Origins of Aortic Coarctation: A Vascular Smooth Muscle Compartment Boundary Model.Journal of developmental biology · 2025Article
- Prostaglandin for Severe Neonatal Coarctation When Arterial Duct Fails to Reopen - To Continue or Not?Indian journal of pediatrics · 2024Article
- The onset of coarctation of the aorta before birth: Mechanistic insights from fetal arch anatomy and haemodynamics.Computers in biology and medicine · 2024Article
- Adaptive Growth of the Ductus Arteriosus and Aortic Isthmus in Various Ductus-Dependent Complex Congenital Heart Diseases.Pediatric cardiology · 2024Article
- Interventional Management of a Rare Case of Complex Congenital Heart Disease in an Adult Patient: A Case Report.The journal of Tehran Heart Center · 2024Article
- Surgically induced aortic coarctation in a neonatal porcine model allows for longitudinal assessment of cardiovascular changes.American journal of physiology. Heart and circulatory physiology · 2024Article
- The role of 3D technology in the practical education of congenital coarctation and its treatment-a feasibility pilot study.BMC medical education · 2024Article
- Simultaneous surgical treatment of aortic coarctation and aortic root disease: a report of case series.Journal of thoracic disease · 2023Article
- Preductal Segmental Tubular Aortic Hypoplasia in Perinatally Died Stabyhoun Puppies.Animals : an open access journal from MDPI · 2023Article
- Coarctation of the Aorta: Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
- Learning the Hidden Signature of Fetal Arch Anatomy: a Three-Dimensional Shape Analysis in Suspected Coarctation of the Aorta.Journal of cardiovascular translational research · 2023Article
- Utility of novel echocardiographic measurements to improve prenatal diagnosis of coarctation of the aorta.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coarctation of the aorta (CoA) is defined as a congenital stenosis of the thoracic aorta and is one of the most common congenital cardiovascular diseases. Despite successful surgical treatment for CoA, arterial abnormalities, including refractory hypertension, aortic aneurysm, and proatherogenic phenotypic changes, frequently affect patients' quality of life. Emerging evidence from morphological and molecular biological investigations suggest that the area of CoA is characterized by phenotypic modulation of smooth muscle cells, intimal thickening, and impaired elastic fiber formation. These changes extend to the pre-and post-stenotic aorta and impair arterial elasticity. The aim of this review is to present current findings on the pathology and molecular mechanisms of vascular remodeling due to CoA. In particular, we will discuss the association between CoA and the ductus arteriosus since the most common site for the stenosis is in the proximity of the ductus arteriosus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.