ReviewThe journal of physiological sciences : JPS2017
Adaptation to microgravity, deconditioning, and countermeasures.
Review in The journal of physiological sciences : JPS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Spaceflight on Musculoskeletal Health: A Systematic Review and Meta-analysis, Considerations for Interplanetary Travel.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Blood flow restriction: The acute effects of body tilting and reduced gravity analogues on limb occlusion pressure.Experimental physiology · 2026Article
- Personalization and Fortification of In-Space Manufactured Emulsified Beverages for Long-Term Space Travel.Comprehensive reviews in food science and food safety · 2026Review
- Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest: BRAVE study.Experimental physiology · 2026Article
- Formulation of Personalized, Fortified Beverage Nanoemulsions for Space Exploration with Omega‑3 Polyunsaturated Fatty Acids.ACS food science & technology · 2026Article
- Simulated Microgravity Induces Rapid Dielectric Shifts in Erythrocytes of Pancreatic Cancer Patients.ACS nanoscience Au · 2026Article
- The effect of artificial gravity on the outcome of a two-week resistance vibration exercise programme: BRAVE study.Experimental physiology · 2026Article
- Dihydropyridine Receptor Inhibition Attenuates Force and Fiber Cross-Sectional Area Decrease in the Three-Day Unloaded Rat Soleus Muscle.International journal of molecular sciences · 2026Article
- Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model.Science advances · 2026Article
- Cosmic silence and viral noise: transcriptomic crosstalk inFrontiers in microbiology · 2026Article
- Neural changes in microgravity: Investigating the effects of aerospace environments.IBRO neuroscience reports · 2025Review
- Review of microgravity's impact on cardiovascular and nervous systems in space exploration.NPJ microgravity · 2025Review
- Increasing seated reaction forces with lower body negative pressure.NPJ microgravity · 2025Article
- Hydrogels in Simulated Microgravity: Thermodynamics at Play.Gels (Basel, Switzerland) · 2025Review
- An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025Review
- Can visual acceleration evoke a sensation of tilt?Experimental brain research · 2025Article
- Repeatability of artificial gravity tolerance times.Frontiers in physiology · 2025Article
- Peripheral skin cooling during gravitational challenges in parabolic flight - experimental protocol, implementation, and case study of the CoolFly experiment.Frontiers in physiology · 2025Article
- Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research.Oncology research · 2025Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans are generally in standing or sitting positions on Earth during the day. The musculoskeletal system supports these positions and also allows motion. Gravity acting in the longitudinal direction of the body generates a hydrostatic pressure difference and induces footward fluid shift. The vestibular system senses the gravity of the body and reflexively controls the organs. During spaceflight or exposure to microgravity, the load on the musculoskeletal system and hydrostatic pressure difference is diminished. Thus, the skeletal muscle, particularly in the lower limbs, is atrophied, and bone minerals are lost via urinary excretion. In addition, the heart is atrophied, and the plasma volume is decreased, which may induce orthostatic intolerance. Vestibular-related control also declines; in particular, the otolith organs are more susceptible to exposure to microgravity than the semicircular canals. Using an advanced resistive exercise device with administration of bisphosphonate is an effective countermeasure against bone deconditioning. However, atrophy of skeletal muscle and the heart has not been completely prevented. Further ingenuity is needed in designing countermeasures for muscular, cardiovascular, and vestibular dysfunctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.