ArticleNeurocritical care2017
Prevalence and Risk Factors for Early Seizure in Patients with Traumatic Brain Injury: Analysis from National Trauma Data Bank.
Article in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Early post-traumatic seizure as severity predictor of traumatic brain injury: A meta-analysis and systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Pooled it
- Clinical risk factors for post-traumatic seizures: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- Pooled it
- Seizure Risk Associated With the Use of Transcranial Magnetic Stimulation for Coma Recovery in Individuals With Disordered Consciousness After Severe Traumatic Brain Injury.The Journal of head trauma rehabilitationPooled it
- Blood biomarker outliers and clinical events during intensive care in patients with traumatic brain injury.Brain & spine · 2026Article
- Article
- Functional outcomes in depressed skull fractures: the role of surgical timing and perioperative clinical radiological predictors.Neurosurgical review · 2025Article
- Risk Stratification for Early Seizures after Traumatic Brain Injury: A Clinical Scoring Model for Prediction and Management.Neurotrauma reports · 2025Article
- Comparison of Effectiveness of Brivaracetam and Levetiracetam for Prophylaxis of Early Post-Traumatic Seizures: A Prospective Comparative Interventional Study.Asian journal of neurosurgery · 2024Article
- Epidemiology, Risk Factors, and Biomarkers of Post-Traumatic Epilepsy: A Comprehensive Overview.Biomedicines · 2024Review
- Article
- Article
- Acute subdural hematoma in an infant with a biphasic clinical course and late reduced diffusion.Surgical neurology international · 2023Article
- Assessing risk factors associated with breakthrough early post-traumatic seizures in patients receiving phenytoin prophylaxis.Frontiers in neurology · 2023Article
- Establishment and validation of PTE prediction model in patients with cerebral contusion.Scientific reports · 2022Article
- Early post-traumatic seizures in hospitalized patients with traumatic brain injury.Acta neurologica Scandinavica · 2022Article
- Mapping spreading depolarisations after traumatic brain injury: a pilot clinical study protocol.BMJ open · 2022Article
- A review of seizures and epilepsy following traumatic brain injury.Journal of neurology · 2020Review
- Traumatic Injury of Major Cerebral Venous Sinuses Associated with Traumatic Brain Injury or Head and Neck Trauma: Analysis of National Trauma Data Bank.Journal of vascular and interventional neurology · 2020Article
- Predictive Risk Factors for Early Seizures in Traumatic Brain Injury.Journal of neurosciences in rural practice · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraumatic brain injury (TBI) is a well-known risk factor for seizures. We aimed to identify the frequency and risk factors for seizure occurrence during hospitalization for TBI.
methodsWe used ICD-9-CM codes to identify patients 18 years of age or older from the National Trauma Data Bank who were admitted with TBI. We also used ICD-9-CM codes to identify the subset who had seizures during hospitalization. Patient demographics, comorbidities, Glasgow Coma Scale (GCS) score, Injury Severity Score Abbreviated Injury Scale (ISSAIS), in-hospital complications, and discharge disposition were compared in the seizure group (SG) and no-seizure group (NSG).
resultsA total of 1559 patients had in-hospital seizures, comprising 0.4% of all patients admitted with TBI. The mean age of SG was 3 years older than NSG [51 vs. 48; p < 0.0001]. African-American ethnicity (20 vs. 12%, p < 0.0001) and moderate TBI (8 vs. 4%, p < 0.0001) were more common in SG. History of alcohol dependence was more common in the SG (25 vs. 11%, p < 0.0001). Fall was the most common mechanism of injury in SG (56 vs. 36% in NSG; p < 0.0001). Subdural hematoma was more common in SG (31 vs. 21%, p < 0.0001). SG had higher rates of pneumonia, ARDS, acute kidney injury, and increased ICP. The average length of hospital stay was significantly higher in SG (10 vs. 6 days, p < 0.0001), and these patients had higher rate of discharge to nursing facility (32 vs. 25%, p < 0.0001).
conclusionIn-hospital seizures occur in 0.4% of all TBI patients. Although infrequent, seizure occurrence is associated with higher rates of hospital complications such as pneumonia and ARDS and is an independent predictor of longer hospital stay and worse hospital outcome.
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