ArticleMolecular and cellular biochemistry2017
hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic.
Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Epididymal dynamics and preimplantation roles of a sperm-enriched 5' fragment of tRNA-valine.Cell reports · 2025Article
- Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS.Nature communications · 2024Article
- A candidate protective factor in amyotrophic lateral sclerosis: heterogenous nuclear ribonucleoprotein G.Neural regeneration research · 2023Article
- Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1-related spectrum.Annals of clinical and translational neurology · 2022Review
- hnRNP A1 in RNA metabolism regulation and as a potential therapeutic target.Frontiers in pharmacology · 2022Review
- Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.Molecular neurodegeneration · 2021Article
- hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.Biology · 2021Review
- Compensatory expression regulation of highly homologous proteins HNRNPA1 and HNRNPA2.Turkish journal of biology = Turk biyoloji dergisi · 2021Article
- The snowball effect of RNA binding protein dysfunction in amyotrophic lateral sclerosis.Brain : a journal of neurology · 2018Article
- Exploring the RNA landscape of endothelial exosomes.RNA (New York, N.Y.) · 2018Article
- Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based onFrontiers in neuroscience · 2018Article
- Genetic mutations in RNA-binding proteins and their roles in ALS.Human genetics · 2017Review
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Authors and funding
2 authors.
Funding
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Abstract
Heterogeneous nuclear ribonucleoprotein (hnRNP)A1, a member of the hnRNP family, is involved in a variety of RNA metabolisms. The hnRNPA1 expression is altered in some human diseases and mutations of the hnRNPA1 gene cause amyotrophic lateral sclerosis and multisystem proteinopathy. It has been therefore assumed that the dysregulation of hnRNPA1 is linked to the pathogenesis of the diseases. However, the mechanism underlying the regulation of the hnRNPA1 expression remains unknown. In this study, using cell-based models, we have found that hnRNPA1 negatively regulates its own mRNA expression by inhibiting the intron10 splicing of hnRNPA1 pre-mRNA. This mechanism likely serves as an autoregulation of the hnRNPA1 expression. We have also found that a low-grade excess of hnRNPA1 expression causes cytotoxicity by activating the mitochondrial apoptosis pathway. Collectively, these data suggest that the level of hnRNPA1 is strictly controlled to be within a certain range by the mRNA autoregulation in the physiological condition so that the cytotoxicity-causative alteration of hnRNPA1 expression does not take place.
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Registered trials
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