ReviewHistochemistry and cell biology2017
The sugar code in neuronal physiology.
Review in Histochemistry and cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Neurocentric No More? Oligodendrocyte Dysfunction Supports Epileptogenesis.Epilepsy currents · 2026Article
- Does Altered Membrane Glycosylation Contribute to Neurodevelopmental Dysfunction in Autism Spectrum Disorder?Membranes · 2026Review
- Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder.International journal of molecular sciences · 2023Article
- Glycans and Carbohydrate-Binding/Transforming Proteins in Axon Physiology.Advances in neurobiology · 2023Article
- Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates.Advances in neurobiology · 2023Article
- Article
- Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes.Neuron · 2022Article
- Glycosylation in Axonal Guidance.International journal of molecular sciences · 2021Review
- Galectins and Their Ligand Glycoconjugates in the Central Nervous System Under Physiological and Pathological Conditions.Frontiers in neuroanatomy · 2021Review
- Analysis of N- and O-Linked Glycosylation: Differential Glycosylation after Rat Spinal Cord Injury.Journal of neurotrauma · 2020Article
- Extracellular heparan sulfate proteoglycans and glycan-binding lectins orchestrateJournal of cell science · 2020Review
- From glycophenotyping by (plant) lectin histochemistry to defining functionality of glycans by pairing with endogenous lectins.Histochemistry and cell biology · 2018Review
- Neurons define non-myelinated axon segments by the regulation of galectin-4-containing axon membrane domains.Scientific reports · 2017Article
- Network analysis of adhesion/growth-regulatory galectins and their binding sites in adult chicken retina and choroid.Journal of anatomy · 2017Article
- Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design.Histochemistry and cell biology · 2017Article
- Galectins: their network and roles in immunity/tumor growth control.Histochemistry and cell biology · 2017Review
- Lipid glycosylation: a primer for histochemists and cell biologists.Histochemistry and cell biology · 2017Review
- C-type lectins: their network and roles in pathogen recognition and immunity.Histochemistry and cell biology · 2017Review
- An introduction to the sugar code.Histochemistry and cell biology · 2017Article
- Sialylation of N-glycans: mechanism, cellular compartmentalization and function.Histochemistry and cell biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbohydrate-related interactions are necessary for the correct development and function of the nervous system. As we illustrate with several examples, those interactions are controlled by carbohydrate-modifying enzymes and by carbohydrate-binding proteins that regulate a plethora of complex axonal processes. Among others, glycan-related proteins as sialidase Neu3 or galectins-1, -3, and -4 play central roles in the determination of axonal fate, axon growth, guidance and regeneration, as well as in polarized axonal glycoprotein transport. In addition, myelination is also highly dependent on glycans, and the stabilization of myelin architecture requires the interaction of the myelin-associated glycoprotein (siglec-4) with gangliosides in the axonal membrane. The roles of glycans in neuroscience are far from being completely understood, though the cases presented here underscore the importance and potential of carbohydrates to establish with precision key molecular mechanisms of the physiology of the nervous system. New specific applications in diagnosis as well as the definition of new molecular targets to treat neurological diseases related to lectins and/or glycans are envisioned in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.