SynthesisEuropean journal of nutrition2018
Association of famine exposure during early life with the risk of type 2 diabetes in adulthood: a meta-analysis.
Synthesis in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early-Life Exposure to the Chinese Famine of 1959-1961 and Type 2 Diabetes in Adulthood: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis.Journal of diabetes research · 2020Pooled it
- Type 5 diabetes: a 70-year perspective and its implications for the Americas.Lancet regional health. Americas · 2025Review
- Early-life famine exposure and subsequent risk of chronic disease comorbidity in later adulthood: the role of social activities.Frontiers in nutrition · 2025Article
- Famine mortality and contributions to later-life type 2 diabetes at the population level: a synthesis of findings from Ukrainian, Dutch and Chinese famines.BMJ global health · 2024Review
- Separate and combined effects of famine exposure and menarche age on metabolic syndrome among the elderly: a cross-sectional study in China.BMC women's health · 2023Article
- Famine exposure in early life and type 2 diabetes in adulthood: findings from prospective studies in China.Nutrition research and practice · 2023Article
- Article
- Metabolites in the association between early-life famine exposure and type 2 diabetes in adulthood over a 5-year follow-up period.BMJ open diabetes research & care · 2021Article
- Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine.Nutrients · 2020Article
- Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood.Nutrition & diabetes · 2020Article
- Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood.International journal of environmental research and public health · 2020Article
- Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood.International journal of environmental research and public health · 2020Article
- Concurrency of Early-Age Exposure to Chinese Famine and Diabetes Increases Recurrence of Ischemic Stroke.Frontiers in neurology · 2020Article
- Famine exposure in early life is associated with visceral adipose dysfunction in adult females.European journal of nutrition · 2019Article
- Chinese famine exposure in infancy and metabolic syndrome in adulthood: results from the China health and retirement longitudinal study.European journal of clinical nutrition · 2019Article
- Famine Exposure in Early Life and Risk of Metabolic Syndrome in Adulthood: Comparisons of Different Metabolic Syndrome Definitions.Journal of diabetes research · 2019Article
- Developmental origins of type 2 diabetes: a perspective from China.European journal of clinical nutrition · 2017Review
- Early-Life Nutritional Programming of Type 2 Diabetes: Experimental and Quasi-Experimental Evidence.Nutrients · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe association between famine exposure (defined as lengthy and continuous deprivation of food) during early life and type 2 diabetes (T2DM) in adulthood remains controversial. A meta-analysis was performed to better clarify the relation of famine exposure to later T2DM risk.
methodsA systematic literature search was performed in PubMed, Web of Science, Embase and China National Knowledge Infrastructure for relevant available articles. The articles were limited to those in English or Chinese from January 1990 to June 2016. Observational studies evaluating the association between famine exposure and T2DM were included. The pooled relative risk (RR) with 95% confidence interval (CI) was used to estimate the effect of famine exposure on T2DM. The I
resultsWe included 11 published articles with 12391 T2DM cases for this meta-analysis. A significant association of early life famine exposure with increased risk of T2DM was observed (RR = 1.38, 95% CI 1.17-1.63; I
conclusionThe meta-analysis indicates that famine exposure during early life especially fetal-infant exposure may increase the risk of T2DM in adulthood. Measures should be taken to prevent malnutrition during important stages of growth and development to reduce the prevalence of T2DM.
Indexed as
Identifiers
27999932What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.