ArticleArchives of toxicology2017
In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.
Article in Archives of toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- A 3D In Vitro Model of the Human Hepatobiliary Junction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dysfunctional macrophages along the gut-liver axis: a driver of infection in cirrhosis.Frontiers in immunology · 2026Review
- Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury-like inflammation.Archives of toxicology · 2025Article
- Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice.EXCLI journal · 2024Article
- Lumped parameter liver simulation to predict acute haemodynamic alterations following partial resections.Journal of the Royal Society, Interface · 2023Article
- Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.Archives of toxicology · 2022Article
- Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins.Archives of toxicology · 2022Article
- Intravital Microscopy to Study Platelet-Leukocyte-Endothelial Interactions in the Mouse Liver.Journal of visualized experiments : JoVE · 2022Article
- From Seeing to Simulating: A Survey of Imaging Techniques and Spatially-Resolved Data for Developing Multiscale Computational Models of Liver Regeneration.Frontiers in systems biology · 2022Article
- Intravital Imaging of Inflammatory Response in Liver Disease.Frontiers in cell and developmental biology · 2022Review
- Article
- Subcellular spatio-temporal intravital kinetics of aflatoxin BArchives of toxicology · 2021Article
- Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers.Frontiers in cell and developmental biology · 2021Article
- Role of autophagy in drug induced liver injury.Archives of toxicology · 2020Article
- Hepatotoxicity of pyrrolizidine alkaloids in rats in relation to human exposure.Archives of toxicology · 2020Article
- Article
- Highlight Report: Hepatobiliary differentiation from human induced pluripotent stem cells.EXCLI journal · 2020Article
- Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated.EXCLI journal · 2020Article
- Kupffer cells in hepatotoxicity.EXCLI journal · 2020Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
We describe a two-photon microscopy-based method to evaluate the in vivo systemic transport of compounds. This method comprises imaging of the intact liver, kidney and intestine, the main organs responsible for uptake and elimination of xenobiotics and endogenous molecules. The image quality of the acquired movies was sufficient to distinguish subcellular structures like organelles and vesicles. Quantification of the movement of fluorescent dextran and fluorescent cholic acid derivatives in different organs and their sub-compartments over time revealed significant dynamic differences. Calculated half-lives were similar in the capillaries of all investigated organs but differed in the specific sub-compartments, such as parenchymal cells and bile canaliculi of the liver, glomeruli, proximal and distal tubules of the kidney and lymph vessels (lacteals) of the small intestine. Moreover, tools to image immune cells, which can influence transport processes in inflamed tissues, are described. This powerful approach provides new possibilities for the analysis of compound transport in multiple organs and can support physiologically based pharmacokinetic modeling, in order to obtain more precise predictions at the whole body scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.