Evidence map›Paper›PMID 27999865›Full record

ArticleJournal of biomedical optics2016

Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy.

Cheng-Hui Liu, Susie Boydston-White, Arel Weisberg, Wubao Wang, Laura A Sordillo, Adler Perotte, Vincent P Tomaselli, Peter P Sordillo, Zhe Pei, Lingyan Shi and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
7.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Cheng-Hui LiuThe City College of the City University of New York, Institute of Ultrafast Spectroscopy and Lasers, Departments of Physics and Electrical Engineering, 160 Convent Avenue, Room MR 201, New York, New York 10031-9101, United States.
Susie Boydston-WhiteThe City University of New York, Borough of Manhattan Community College, 199 Chambers Street, N682, New York, New York 10007-1097, United States.
Arel WeisbergEnergy Research Company, 1250 South Avenue, Plainfield, New Jersey 07062, United States.
Wubao WangThe City College of the City University of New York, Institute of Ultrafast Spectroscopy and Lasers, Departments of Physics and Electrical Engineering, 160 Convent Avenue, Room MR 201, New York, New York 10031-9101, United States.
Laura A SordilloThe City College of the City University of New York, Institute of Ultrafast Spectroscopy and Lasers, Departments of Physics and Electrical Engineering, 160 Convent Avenue, Room MR 201, New York, New York 10031-9101, United States.
Adler PerotteColumbia University Medical Center, Department of Biomedical Informatics, 622 West 168th Street, PH20, New York, New York 10032, United States.
Vincent P TomaselliColumbia University Medical Center, Department of Biomedical Informatics, 622 West 168th Street, PH20, New York, New York 10032, United States.
Peter P SordilloThe City College of the City University of New York, Institute of Ultrafast Spectroscopy and Lasers, Departments of Physics and Electrical Engineering, 160 Convent Avenue, Room MR 201, New York, New York 10031-9101, United States.
Zhe PeiThe City College of the City University of New York, Institute of Ultrafast Spectroscopy and Lasers, Departments of Physics and Electrical Engineering, 160 Convent Avenue, Room MR 201, New York, New York 10031-9101, United States.
Lingyan ShiThe City College of the City University of New York, Institute of Ultrafast Spectroscopy and Lasers, Departments of Physics and Electrical Engineering, 160 Convent Avenue, Room MR 201, New York, New York 10031-9101, United StateseColumbia University, Department of Chemistry, 3000 Broadway MC 3139, New York, New York 10027, United States.
Robert R AlfanoThe City College of the City University of New York, Institute of Ultrafast Spectroscopy and Lasers, Departments of Physics and Electrical Engineering, 160 Convent Avenue, Room MR 201, New York, New York 10031-9101, United States.
City College of New York · USColumbia University Irving Medical Center · USBorough of Manhattan Community College · USColumbia University · USEnergy Research Company (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A clear correlation has been observed between the resonance Raman (RR) spectra of plaques in the aortic tunica intimal wall of a human corpse and three states of plaque evolution: fibrolipid plaques, calcified and ossified plaques, and vulnerable atherosclerotic plaques (VPs). These three states of atherosclerotic plaque lesions demonstrated unique RR molecular fingerprints from key molecules, rendering their spectra unique with respect to one another. The vibrational modes of lipids, cholesterol, carotenoids, tryptophan and heme proteins, the amide I, II, III bands, and methyl/methylene groups from the intrinsic atherosclerotic VPs in tissues were studied. The salient outcome of the investigation was demonstrating the correlation between RR measurements of VPs and the thickness measurements of fibrous caps on VPs using standard histopathology methods, an important metric in evaluating the stability of a VP. The RR results show that VPs undergo a structural change when their caps thin to 66 ?? ? m , very close to the 65 - ? m empirical medical definition of a thin cap fibroatheroma plaque, the most unstable type of VP.

Indexed as

Aged, 80 and overAortaCarotenoidsCholesterolDiagnosis, Computer-AssistedFemaleHumansLipidsMolecular ImagingPlaque, AtheroscleroticSpectrum Analysis, RamanTryptophanCarotenoidsCholesterolLipidsTryptophan

Identifiers

PMID27999865
PMCPMC5174785
OpenAlexW2564948916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.