Evidence map›Paper›PMID 27999860›Full record

ArticleJournal of biomedical optics2016

Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation.

Colin Schlosser, Nico Bodenschatz, Sylvia Lam, Marette Lee, Jessica N McAlpine, Dianne M Miller, Dirk J T Van Niekerk, Michele Follen, Martial Guillaud, Calum E MacAulay and 1 more

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Probe-based confocal laser endomicroscopy for prediction of uterine rejection in a patient submitted to live-donor uterus transplantation.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026
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  15. Optical techniques for cervical neoplasia detection.Beilstein journal of nanotechnology · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Colin SchlosserBritish Columbia Cancer Research Centre, Department of Integrative Oncology, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Nico BodenschatzBritish Columbia Cancer Research Centre, Department of Integrative Oncology, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Sylvia LamBritish Columbia Cancer Research Centre, Department of Integrative Oncology, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Marette LeeUniversity of British Columbia, Division of Gynecologic Oncology, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada.
Jessica N McAlpineUniversity of British Columbia, Division of Gynecologic Oncology, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada.
Dianne M MillerUniversity of British Columbia, Division of Gynecologic Oncology, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada.
Dirk J T Van NiekerkBritish Columbia Cancer Agency, Department of Pathology, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada.
Michele FollenBrookdale University Hospital and Medical Center, One Brookdale Plaza, Brooklyn, New York 11212, United States.
Martial GuillaudBritish Columbia Cancer Research Centre, Department of Integrative Oncology, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Calum E MacAulayBritish Columbia Cancer Research Centre, Department of Integrative Oncology, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Pierre M LaneBritish Columbia Cancer Research Centre, Department of Integrative Oncology, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.

Funding

Technical FeasibilityP01CA082710 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MACAULAY, CALUM E · 1999 to 2014
$28.7M
NCI NIH HHS P01 CA082710
6 · The paper itself

Abstract

Current diagnostic capabilities and limitations of fluorescence endomicroscopy in the cervix are assessed by qualitative and quantitative image analysis. Four cervical tissue types are investigated: normal columnar epithelium, normal and precancerous squamous epithelium, and stromal tissue. This study focuses on the perceived variability within and the subtle differences between the four tissue groups in the context of endomicroscopic in vivo pathology. Conclusions are drawn on the general ability to distinguish and diagnose tissue types, on the need for imaging depth control to enhance differentiation, and on the possible risks for diagnostic misinterpretations.

Indexed as

Cervix UteriEpithelial CellsEquipment DesignFemaleHumansMicroscopy, ConfocalMicroscopy, FluorescencePilot ProjectsSquamous Intraepithelial Lesions of the Cervix

Identifiers

PMID27999860
PMCPMC8357321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.