Evidence map›Paper›PMID 27999837›Full record

ArticleChemical communications (Cambridge, England)2017

Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels.

Weiqi Zhang, Zhe Zhang, Ching-Hsuan Tung

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. CuPharmaceutics · 2022
    Article
  6. Article
  7. Review
  8. Review
  9. Redox-responsive cisplatin nanogels for anticancer drug delivery.Chemical communications (Cambridge, England) · 2018
    Article
  10. Article
  11. Sequence-Independent DNA Nanogel as a Potential Drug Carrier.Macromolecular rapid communications · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Weiqi ZhangMolecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, Cornell University, 413 East 69th Street, Box 290, New York, NY 10021, USA. cht2018@med.cornell.edu.
Zhe ZhangMolecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, Cornell University, 413 East 69th Street, Box 290, New York, NY 10021, USA. cht2018@med.cornell.edu.ORCID http://orcid.org/0000-0003-4331-7887
Ching-Hsuan TungMolecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, Cornell University, 413 East 69th Street, Box 290, New York, NY 10021, USA. cht2018@med.cornell.edu.

Funding

Sound excitable drugsR01GM094880 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TUNG, CHING-HSUAN · 2010 to 2014
$1.2M
NIGMS NIH HHS R01 GM094880
6 · The paper itself

Abstract

A cisplatin templated nanogel with targeting capability was synthesized, inspired by cisplatin as a chemotherapeutic drug. After crosslinking the natural polysaccharide hyaluronan, a ligand for CD44, cisplatin could be removed by simple dialysis in a salt solution while the withheld drug remains entrapped.

Indexed as

Antineoplastic AgentsCell ProliferationCisplatinDose-Response Relationship, DrugDrug CarriersDrug Screening Assays, AntitumorHumansHyaluronic AcidMolecular StructureNanostructuresStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsCisplatinDrug CarriersHyaluronic Acid

Identifiers

PMID27999837
PMCPMC5319414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.