ArticleEmerging microbes & infections2016
Characterization of community-associated Staphylococcus aureus from skin and soft-tissue infections: a multicenter study in China.
Article in Emerging microbes & infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2021Pooled it
- Community-genotype methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Latin America: a systematic review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesPooled it
- Article
- Insight into the molecular characteristics of community-associated Staphylococcus aureus isolates from pediatric patients in South China.BMC microbiology · 2026Article
- Genomic and clinical characteristics ofMicrobiology spectrum · 2026Article
- Clinical and molecular characteristics of Staphylococcus aureus isolates from patients with COVID-19 in Southwest China.BMC infectious diseases · 2025Article
- Clinical Features and Antibiotic Susceptibility ofJournal of clinical medicine · 2025Article
- Article
- Mupirocin for Skin Infection: Clinical Experience from China.Infection and drug resistance · 2024Review
- Comparative analysis of genomic characteristics, virulence and fitness of community-associatedVirulence · 2023Article
- Antibiotic susceptibility and clonal distribution ofFrontiers in cellular and infection microbiology · 2023Article
- MRSA in Humans, Pets and Livestock in Portugal: Where We Came from and Where We Are Going.Pathogens (Basel, Switzerland) · 2022Review
- Antibiotic-resistant profile and the factors affecting the intravenous antibiotic treatment course of generalized Staphylococcal Scalded Skin Syndrome: a retrospective study.Italian journal of pediatrics · 2021Article
- Clinical and molecular characteristics of Staphylococcus aureus isolated from Chinese children: association among the agr groups and genotypes, virulence genes and disease types.World journal of pediatrics : WJP · 2021Article
- Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells.Infection and immunity · 2020Article
- Phenotypic and Molecular Characteristics of Community-AssociatedInfection and drug resistance · 2020Article
- Molecular Characteristics, Virulence Gene and Wall Teichoic Acid Glycosyltransferase Profiles ofFrontiers in microbiology · 2020Article
- The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains.Molecules (Basel, Switzerland) · 2019Article
- Molecular Epidemiology ofJournal of Korean medical science · 2019Article
- Characterisation of community-acquiredEpidemiology and infection · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the epidemiological and molecular features of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and methicillin-sensitive S. aureus (MSSA) from children and adult patients with skin and soft-tissue infections (SSTIs) in China. Prospective community-acquired S. aureus SSTI surveillance was conducted in 23 hospitals over a 24-month period. Susceptibility to 16 antimicrobials was evaluated using the agar dilution method. StatApriori was used to determine statistically significant association trends. The genotypic characteristics of CA-MRSA isolates were tested by staphylococcal cassette chromosome mec (SCCmec) typing, staphylococcal protein A (spa) typing, and multilocus sequence typing. The presence of Panton-Valentine leukocidin (pvl) genes was determined. Overall, 71.6% (1946/2716) of cases were community-associated S. aureus. CA-MRSA accounted for 2.6% (51). Out of 1895 methicillin-sensitive S. aureus strains, 97.3% were resistant to erythromycin, 96.6% to penicillin and 89.1% to clindamycin. No S. aureus strains were resistant to vancomycin. Thirteen sequence types (STs) and 17 spa types were detected among the CA-MRSA strains. The most prevalent sequence type was ST121 (19/51, 37.3%), followed by ST59 (13/51, 25.5%). In addition, t437 was predominant, accounting for 43.1% (22/51). Only five (9.8%) of the CA-MRSA strains harbored pvl genes. There were no significant differences in antibiotic sensitivity profiles between ST121 and non-ST121 MRSA isolates. However, ST121 strains tended to be more resistant to cefazolin, whereas non-ST121 strains were more resistant to chloramphenicol. In conclusion, CA-MRSA infections are rare among Chinese SSTI patients. MRSA strains in China have diverse genetic backgrounds, with ST121 being the predominant clone. Fusidic acid and mupirocin remain effective for topical treatment.
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