Evidence map›Paper›PMID 27999401›Full record

ArticleInternational journal of molecular sciences2016

Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.

Andrea Párniczky, Eszter Hegyi, Anna Zsófia Tóth, Ákos Szücs, Andrea Szentesi, Áron Vincze, Ferenc Izbéki, Balázs Csaba Németh, Péter Hegyi, Miklós Sahin-Tóth

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test.American journal of physiology. Gastrointestinal and liver physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Andrea PárniczkyCenter for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118, USA. andrea.parniczky@gmail.com.
Eszter HegyiCenter for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118, USA. heszter@bu.edu.
Anna Zsófia TóthCenter for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118, USA. tothannadr@gmail.com.
Ákos SzücsFirst Department of Surgery, Semmelweis University, 1082 Budapest, Hungary. szucs.akos@gmail.com.
Andrea SzentesiInstitute for Translational Medicine, University of Pécs, 7624 Pécs, Hungary. szentesiai@gmail.com.
Áron VinczeFirst Department of Medicine, University of Pécs, 7624 Pécs, Hungary. vincze.aron@pte.hu.
Ferenc IzbékiDepartment of Gastroenterology, St. George Teaching Hospital of County Fejér, 8000 Székesfehérvár, Hungary. fizbeki@gmail.com.
Balázs Csaba NémethFirst Department of Medicine, University of Szeged, 6720 Szeged, Hungary. nemeth.balazs@med.u-szeged.hu.
Péter HegyiInstitute for Translational Medicine, University of Pécs, 7624 Pécs, Hungary. hegyi2009@gmail.com.
Miklós Sahin-TóthCenter for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118, USA. miklos@bu.edu.
Boston University · USUniversity of Pecs · HUUniversity of Szeged · HUKodolányi János University of Applied Sciences · HUSemmelweis University · HU

Funding

Chymotrypsin in pancreatitisR01DK082412 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2009 to 2024
$5.8M
Molecular Pathomechanism of Hereditary PancreatitisR01DK058088 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2001 to 2019
$5.3M
Pancreatic elastasesR01DK095753 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SAHIN-TOTH, MIKLOS · 2013 to 2016
$1.4M
NIDDK NIH HHS R01 DK058088NIDDK NIH HHS R01 DK082412NIDDK NIH HHS R01 DK095753
6 · The paper itself

Abstract

Human chymotrypsin-like elastases 3A and 3B (CELA3A and CELA3B) are the products of gene duplication and share 92% identity in their primary structure. CELA3B forms stable complexes with procarboxypeptidases A1 and A2 whereas CELA3A binds poorly due to the evolutionary substitution of Ala241 with Gly in exon 7. Since position 241 is polymorphic both in

Indexed as

Base SequenceCarboxypeptidasesCell LineEnzyme PrecursorsFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHEK293 CellsHumansMaleMiddle AgedMutation, MissensePancreasPancreatic ElastasePancreatitis, ChronicCarboxypeptidasesCELA3A protein, humanCELA3B protein, humanEnzyme PrecursorsPancreatic Elastaseproelastasechronic pancreatitisdigestive proteaseelastasepancreaszymogen complexes

Identifiers

PMID27999401
PMCPMC5187948
OpenAlexW2561928698

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.