Evidence map›Paper›PMID 27999323›Full record

ArticleInternational journal of molecular sciences2016

Circulating Cell-Free DNA Levels Could Predict Oncological Outcomes of Patients Undergoing Esophagectomy for Esophageal Squamous Cell Carcinoma.

Chih-Cheng Hsieh, Han-Shui Hsu, Shih-Ching Chang, Yann-Jang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  6. Review
  7. Article
  8. Current management of gastric adenocarcinoma: a narrative review.Journal of gastrointestinal oncology · 2023
    Review
  9. Article
  10. New Perspectives on the Importance of Cell-Free DNA Biology.Diagnostics (Basel, Switzerland) · 2022
    Review
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  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Chih-Cheng HsiehInstitute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. cchsieh2@vghtpe.gov.tw.
Han-Shui HsuDivision of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan. hsuhs@vghtpe.gov.tw.
Shih-Ching ChangDepartment of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. changsc@vghtpe.gov.tw.
Yann-Jang ChenInstitute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. yjchen@ym.edu.tw.
National Yang Ming Chiao Tung University · TWNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating cell-free DNA (cfDNA) is a potential biomarker for cancer progression but its role is unclear in patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy. We investigated relationships between plasma cfDNA levels and clinicopathological parameters in ESCC patients. Eighty-one ESCC patients who received esophagectomy were enrolled. Plasma samples from these patients and 95 normal controls were collected. DNA copy numbers were measured by real-time quantitative PCR. Subjects were divided into two groups by cfDNA level. Clinicopathological data were collected retrospectively and relationships between cfDNA levels and clinical parameters were evaluated. The cfDNA level in normal controls ranged from 0-4157 copies/mL. The cfDNA level of 96.3% ESCC patients was higher than the cutoff value (2447.26 copies/mL) with a specificity of 94.1%. The mean cfDNA concentration was 5918 copies/mL in lower and 53,311 copies/mL in higher cfDNA groups. No correlations were found between clinicopathological factors and cfDNA levels except for lymphovascular invasion. Higher cfDNA levels were associated with tumor relapse (

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Squamous CellDisease-Free SurvivalDNAEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalBiomarkers, TumorDNAcirculating cell-free DNAesophageal squamous cell carcinomasurvival

Identifiers

PMID27999323
PMCPMC5187931
OpenAlexW2561095783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.