Evidence map›Paper›PMID 27999265›Full record

ArticleInternational journal of molecular sciences2016

Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.

Angela Lopomo, Roberta Ricciardi, Michelangelo Maestri, Anna De Rosa, Franca Melfi, Marco Lucchi, Alfredo Mussi, Fabio Coppedè, Lucia Migliore

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Thymic Epithelial Tumors: An Evolving Field.Life (Basel, Switzerland) · 2023
    Review
  3. Review
  4. Review
  5. Thymic Epithelial Neoplasms: Focusing on the Epigenetic Alterations.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Epigenetics of Male Infertility: The Role of DNA Methylation.Frontiers in cell and developmental biology · 2021
    Review
  10. Investigation ofFrontiers in molecular neuroscience · 2020
    Article
  11. Article
  12. Association of Polymorphisms in Genes Involved in One-Carbon Metabolism withInternational journal of molecular sciences · 2019
    Article
  13. Article
  14. Tumor Microenvironment and Metabolism.International journal of molecular sciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Angela LopomoDepartment of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. angela.lopomo@student.unisi.it.
Roberta RicciardiDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. r.ricciardi@ao-pisa.toscana.it.
Michelangelo MaestriDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. michelangelo.mvg@tin.it.
Anna De RosaDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. annu.derosa@hotmail.it.
Franca MelfiDivision of Thoracic Surgery, Cardiothoracic and Vascular Surgery Department, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. franca.mamelfi@gmail.com.
Marco LucchiDivision of Thoracic Surgery, Cardiothoracic and Vascular Surgery Department, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. marco.lucchi@unipi.it.
Alfredo MussiDivision of Thoracic Surgery, Cardiothoracic and Vascular Surgery Department, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. a.mussi@dc.med.unipi.it.
Fabio CoppedèDepartment of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. fabio.coppede@med.unipi.it.
Lucia MiglioreDepartment of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy. lucia.migliore@med.unipi.it.
University of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymomas are uncommon neoplasms that arise from epithelial cells of the thymus and are often associated with myasthenia gravis (MG), an autoimmune disease characterized by autoantibodies directed to different targets at the neuromuscular junction. Little is known, however, concerning epigenetic changes occurring in thymomas from MG individuals. To further address this issue, we analyzed DNA methylation levels of genes involved in one-carbon metabolism (

Indexed as

DNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ADNA Methyltransferase 3BEpithelial CellsHumansMethylenetetrahydrofolate Reductase (NADPH2)Myasthenia GravisPromoter Regions, GeneticThymomaThymus GlandThymus NeoplasmsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDNMT1 protein, humanDNMT3A protein, humanMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humancancerDNA methylationDNMT3AepigeneticsMTHFRmyasthenia gravisthymoma

Identifiers

PMID27999265
PMCPMC5187921
OpenAlexW2561327690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.