ArticleInternational journal of molecular sciences2016
Systematic Understanding of Mechanisms of a Chinese Herbal Formula in Treatment of Metabolic Syndrome by an Integrated Pharmacology Approach.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- Long-term traditional Chinese medicine use and incidence of metabolic syndrome in schizophrenia: a retrospective cohort study.Frontiers in pharmacology · 2026Article
- Identification of Bioactive Compounds from Citri Reticulatae Pericarpium and Evaluation of Their Uric Acid-Lowering Activity.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Article
- AI-assisted literature exploration of innovative Chinese medicine formulas.Frontiers in pharmacology · 2024Article
- Catechin Mediates Ferroptosis to Exert an Anti-Inflammatory Effect on RAW 264.7 Cells.Foods (Basel, Switzerland) · 2022Article
- Herbal drug discovery for the treatment of nonalcoholic fatty liver disease.Acta pharmaceutica Sinica. B · 2020Review
- Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer.Frontiers in pharmacology · 2020Article
- Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective.Chinese journal of integrative medicine · 2020Review
- Folic Acid Has a Protective Effect on Retinal Vascular Endothelial Cells against High Glucose.Molecules (Basel, Switzerland) · 2018Article
- Identfication of Potent LXRβ-Selective Agonists without LXRα Activation by In Silico Approaches.Molecules (Basel, Switzerland) · 2018Article
- Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease.Frontiers in physiology · 2018Article
- Anticancer drug discovery from Chinese medicinal herbs.Chinese medicine · 2018Review
- Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.Frontiers in pharmacology · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome (MS) is becoming a worldwide health problem. Wendan decoction (WDD)-a famous traditional Chinese medicine formula-has been extensively employed to relieve syndromes related to MS in clinical practice in China. However, its pharmacological mechanisms still remain vague. In this study, a comprehensive approach that integrated chemomics, principal component analysis, molecular docking simulation, and network analysis was established to elucidate the multi-component and multi-target mechanism of action of WDD in treatment of MS. The compounds in WDD were found to possess chemical diversity, complexity and drug-likeness compared to MS drugs. Six nuclear receptors were obtained to have strong binding affinity with 217 compounds of five herbs in WDD. The importance roles of targets and herbs were also identified due to network parameters. Five compounds from
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