ArticleProceedings of the National Academy of Sciences of the United States of America2017
Chiral twist drives raft formation and organization in membranes composed of rod-like particles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Stimuli-responsive self-regulating assembly of chiral colloids for robust size and shape control.Nature communications · 2024Article
- Spiral packing and chiral selectivity in model membranes probed by phase-resolved sum-frequency generation microscopy.Nature communications · 2024Article
- Controlling the shape and topology of two-component colloidal membranes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- All twist and no bend makes raft edges splay: Spontaneous curvature of domain edges in colloidal membranes.Science advances · 2020Article
- Conformational switching of chiral colloidal rafts regulates raft-raft attractions and repulsions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Curvature instability of chiral colloidal membranes on crystallization.Nature communications · 2017Article
- Assessing anesthetic activity through modulation of the membrane dipole potential.Journal of lipid research · 2017Article
- Equilibrium mechanisms of self-limiting assembly.Reviews of modern physicsArticle
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid rafts are hypothesized to facilitate protein interaction, tension regulation, and trafficking in biological membranes, but the mechanisms responsible for their formation and maintenance are not clear. Insights into many other condensed matter phenomena have come from colloidal systems, whose micron-scale particles mimic basic properties of atoms and molecules but permit dynamic visualization with single-particle resolution. Recently, experiments showed that bidisperse mixtures of filamentous viruses can self-assemble into colloidal monolayers with thermodynamically stable rafts exhibiting chiral structure and repulsive interactions. We quantitatively explain these observations by modeling the membrane particles as chiral liquid crystals. Chiral twist promotes the formation of finite-sized rafts and mediates a repulsion that distributes them evenly throughout the membrane. Although this system is composed of filamentous viruses whose aggregation is entropically driven by dextran depletants instead of phospholipids and cholesterol with prominent electrostatic interactions, colloidal and biological membranes share many of the same physical symmetries. Chiral twist can contribute to the behavior of both systems and may account for certain stereospecific effects observed in molecular membranes.
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Registered trials
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