ArticleMolecular biology and evolution2017
The Composite Regulatory Basis of the Large X-Effect in Mouse Speciation.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 80 citations in OpenAlex.
- Dynamic regulation of spermatogenesis and hybrid sterility revealed by single-cell analysis in yak and cattle.Molecular biology and evolution · 2026Article
- The X chromosome and the emergence of reproductive isolation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mouse X-linked microRNA cluster regulates the meiotic checkpoint andProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phylogenomic timetree-calibrated speciation clocks for Caenorhabditis nematodes reveal slow but disproportionate accumulation of post-zygotic reproductive isolation.PLoS genetics · 2025Article
- Hybridization and gene expression: Beyond differentially expressed genes.Molecular ecology · 2025Review
- Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses.Genetics · 2025Article
- Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses.bioRxiv : the preprint server for biology · 2024Article
- Toward telomere-to-telomere cat genomes for precision medicine and conservation biology.Genome research · 2024Review
- Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?Evolution; international journal of organic evolution · 2024Article
- Pericentromeric recombination suppression and the 'large X effect' in plants.Scientific reports · 2023Article
- Single-haplotype comparative genomics provides insights into lineage-specific structural variation during cat evolution.Nature genetics · 2023Article
- A polygenic explanation for Haldane's rule in butterflies.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Extraordinary selection on the human X chromosome associated with archaic admixture.Cell genomics · 2023Article
- The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice.Genetics · 2022Article
- The Evolution of Widespread Recombination Suppression on the Dwarf Hamster (Phodopus) X Chromosome.Genome biology and evolution · 2022Article
- Stage-specific disruption of X chromosome expression during spermatogenesis in sterile house mouse hybrids.G3 (Bethesda, Md.) · 2022Article
- Molecular Evolution across Mouse Spermatogenesis.Molecular biology and evolution · 2022Article
- Unraveling patterns of disrupted gene expression across a complex tissue.Evolution; international journal of organic evolution · 2022Article
- Limited Introgression between Rock-Wallabies with Extensive Chromosomal Rearrangements.Molecular biology and evolution · 2022Article
- Rapid Macrosatellite Evolution Promotes X-Linked Hybrid Male Sterility in a Feline Interspecies Cross.Molecular biology and evolution · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The disruption of meiotic sex chromosome inactivation (MSCI) has been proposed to be a major developmental mechanism underlying the rapid evolution of hybrid male sterility. We tested this idea by analyzing cell-specific gene expression across spermatogenesis in two lineages of house mice and their sterile and fertile reciprocal hybrids. We found pervasive disruption of sex chromosome gene expression in sterile hybrids at every stage of spermatogenesis. Failure of MSCI was developmentally preceded by increased silencing of autosomal genes, supporting the hypothesis that divergence at the hybrid incompatibility gene, Prdm9, results in increased rates of autosomal asynapsis which in turn triggers widespread silencing of unsynapsed chromatin. We also detected opposite patterns of postmeiotic overexpression or hyper-repression of the sex chromosomes in reciprocal hybrids, supporting the hypothesis that genomic conflict has driven functional divergence that leads to deleterious X-Y dosage imbalances in hybrids. Our developmental timeline also exposed more subtle patterns of mitotic misregulation on the X chromosome, a previously undocumented stage of spermatogenic disruption in this cross. These results indicate that multiple hybrid incompatibilities have converged on a common regulatory phenotype, the disrupted expression of the sex chromosomes during spermatogenesis. Collectively, these data reveal a composite regulatory basis to hybrid male sterility in mice that helps resolve the mechanistic underpinnings of the well-documented large X-effect in mice speciation. We propose that the inherent sensitivity of spermatogenesis to X-linked regulatory disruption has the potential to be a major driver of reproductive isolation in species with chromosomal sex determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.