ArticleThe Journal of experimental medicine2017
Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Intratumoral microenvironment remodeling by lncRNA ROLLCSC enhances lung adenocarcinoma progression.Genes & diseases · 2026Article
- Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency.Stem cell reports · 2025Article
- Integrin-Alpha-6+ Cells Are Responsible for Blastema Formation During Oral Siphon Regeneration in Ciona robusta.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Targeting metastasis in paediatric bone sarcomas.Molecular cancer · 2025Review
- Review
- The role of the haematopoietic stem cell niche in development and ageing.Nature reviews. Molecular cell biology · 2025Review
- Cellular crosstalk in the bone marrow niche.Journal of translational medicine · 2024Review
- Targeting CDC42 reduces skeletal degeneration after hematopoietic stem cell transplantation.Blood advances · 2024Article
- Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300.Haematologica · 2023Article
- Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2.Communications biology · 2022Article
- Frizzled-6 promotes hematopoietic stem/progenitor cell mobilization and survival during LPS-induced emergency myelopoiesis.Stem cell reports · 2022Article
- Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis.The Journal of clinical investigation · 2022Article
- Article
- Prime-seq, efficient and powerful bulk RNA sequencing.Genome biology · 2022Article
- Article
- Article
- The EHA Research Roadmap: Normal Hematopoiesis.HemaSphere · 2021Article
- Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells.Haematologica · 2021Article
- WNT5A from the fetal liver vascular niche supports human fetal liver hematopoiesis.Stem cell research & therapy · 2021Article
- Cathepsin K maintains the compartment of bone marrow T lymphocytes in vivo.Immunity, inflammation and disease · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 2 countries.
Christina SchreckThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Rouzanna IstvánffyThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.ORCID 0000-0001-6652-9802
Christoph ZiegenhainAnthropology and Human Genomics, Department of Biology II, Ludwig-Maximilian-Universität, 81377 Munich, Germany.ORCID 0000-0003-2208-4877
Theresa SippenauerThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Franziska RufThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Lynette HenkelDepartment of Medical Microbiology, Immunology, and Hygiene, Technische Universität München, 81675 Munich, Germany.
Florian GärtnerDepartment of Internal Medicine I, Ludwig-Maximilian-Universität, 81377 Munich, Germany.ORCID 0000-0001-6120-3723
Beate ViethAnthropology and Human Genomics, Department of Biology II, Ludwig-Maximilian-Universität, 81377 Munich, Germany.
M Carolina FlorianInstitute of Molecular Medicine, University of Ulm, 89081 Ulm, Germany.ORCID 0000-0002-5791-1310
Nicole MendeRegeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, TU Dresden, 01309 Dresden, Germany.ORCID 0000-0002-5078-2333
Anna TaubenbergerBiotechnology Center TU Dresden, 01307 Dresden, Germany.
Áine PrendergastGerman Cancer Research Center (DKFZ) and Heidelberg Institute for Stem Cell Technology and Experimental Medicine, 69120 Heidelberg, Germany.
Alina WagnerThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Charlotta PagelThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Sandra GrziwokThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Katharina S GötzeThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Jochen GuckBiotechnology Center TU Dresden, 01307 Dresden, Germany.ORCID 0000-0002-1453-6119
Douglas C DeanMolecular Targets Program, James Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202.
Steffen MassbergDepartment of Internal Medicine I, Ludwig-Maximilian-Universität, 81377 Munich, Germany.
Marieke EssersGerman Cancer Research Center (DKFZ) and Heidelberg Institute for Stem Cell Technology and Experimental Medicine, 69120 Heidelberg, Germany.
Claudia WaskowRegeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, TU Dresden, 01309 Dresden, Germany.
Hartmut GeigerInstitute of Molecular Medicine, University of Ulm, 89081 Ulm, Germany.
Mathias SchiemannDepartment of Medical Microbiology, Immunology, and Hygiene, Technische Universität München, 81675 Munich, Germany.
Christian PeschelThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.ORCID 0000-0003-0547-2886
Wolfgang EnardAnthropology and Human Genomics, Department of Biology II, Ludwig-Maximilian-Universität, 81377 Munich, Germany.ORCID 0000-0002-4056-0550
Robert A J OostendorpThird Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany robert.oostendorp@tum.de.ORCID 0000-0002-4947-0412
TUM Klinikum · DELudwig-Maximilians-Universität München · DEGerman Cancer Research Center · DETechnische Universität Dresden · DETechnical University of Munich · DEUniversität Ulm · DEUniversity of Louisville · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we show that the Wnt5a-haploinsufficient niche regenerates dysfunctional HSCs, which do not successfully engraft in secondary recipients. RNA sequencing of the regenerated donor Lin
Indexed as
Actin CytoskeletonAnimalsFusion Proteins, bcr-ablHaploinsufficiencyHematopoietic Stem CellsLeukemiaMiceMice, Inbred C57BLRegenerationWnt-5a ProteinFusion Proteins, bcr-ablWnt-5a ProteinWnt5a protein, mouse
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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.