ArticleBMJ open2016
Introduction of standard measles vaccination in an urban African community in 1979 and overall child survival: a reanalysis of data from a cohort study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The mortality effects of disregarding the strategy to save doses of measles vaccine: a cluster-randomised trial in Guinea-Bissau.BMJ global health · 2021Trial
- The origin of non-specific effects of vaccines and the role of randomised clinical trials.Human vaccines & immunotherapeutics · 2026Review
- Article
- Evidence of Increase in Mortality After the Introduction of Diphtheria-Tetanus-Pertussis Vaccine to Children Aged 6-35 Months in Guinea-Bissau: A Time for Reflection?Frontiers in public health · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo examine the effect of the first introduction of measles vaccine (MV) in Guinea-Bissau in 1979.
settingUrban community study of the anthropometric status of all children under 6 years of age.
participantsThe study cohort included 1451 children in December 1978; 82% took part in the anthropometric survey. The cohort was followed for 2 years.
interventionIn December 1979, the children were re-examined anthropometrically. The participating children, aged 6 months to 6 years, were offered MV if they did not have a history of measles infection. There were no routine vaccinations in 1979-1980. PRIMARY AND SECONDARY OUTCOME MEASURES: Age-adjusted mortality rate ratios (MRRs) for measles vaccinated and not vaccinated children; changes in nutritional status.
resultsThe nutritional status deteriorated significantly from 1978 to 1979. Nonetheless, children who received MV at the December 1979 examination had significantly lower mortality in the following year (1980) compared with the children who had been present in the December 1978 examination but were not measles vaccinated. Among children still living in the community in December 1979, measles-vaccinated children aged 6-71 months had a mortality rate of 18/1000 person-years during the following year compared with 51/1000 person-years for absent children who were not measles vaccinated (MRR=0.30 (0.12-0.73)). The effect of MV was not explained by prevention of measles infection as the unvaccinated children did not die of measles infection.
conclusionsMV may have beneficial non-specific effects on child survival not related to the prevention of measles infection.
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