ArticleThe American journal of pathology2017
IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever.
Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Growth differentiation factor-15 as a potential biomarker in subclinical inflammation in familial mediterranean fever.Clinical rheumatology · 2026Article
- Retinal changes in children with Familial Mediterranean Fever: the effect of chronic subclinical inflammation.Pediatric research · 2026Article
- Arterial Stiffness and Subclinical Inflammation in Children with Familial Mediterranean Fever: A Comprehensive Analysis.Children (Basel, Switzerland) · 2025Article
- Induced pluripotent stem cell-derived macrophages as a platform for modelling human disease.Nature reviews. Immunology · 2025Review
- Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis.Seminars in immunology · 2023Review
- Galantamine attenuates autoinflammation in a mouse model of familial mediterranean fever.Molecular medicine (Cambridge, Mass.) · 2022Article
- The Regulation and Modification of GSDMD Signaling in Diseases.Frontiers in immunology · 2022Review
- Techniques to Study Inflammasome Activation and Inhibition by Small Molecules.Molecules (Basel, Switzerland) · 2021Review
- RIPK3 PromotesJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- A comprehensive guide to studying inflammasome activation and cell death.Nature protocols · 2020Article
- The pyrin inflammasome and the Yersinia effector interaction.Immunological reviews · 2020Review
- Intracellular innate immune receptors: Life inside the cell.Immunological reviews · 2020Article
- Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis.Cold Spring Harbor perspectives in biology · 2020Review
- Inflammasomes in the pathophysiology of autoinflammatory syndromes.Journal of leukocyte biology · 2020Review
- Cell death-mediated cytokine release and its therapeutic implications.The Journal of experimental medicine · 2019Review
- TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.The Journal of clinical investigation · 2019Article
- SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.Immunity · 2018Article
- GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.The Journal of experimental medicine · 2018Article
- Function and regulation of IL-1α in inflammatory diseases and cancer.Immunological reviews · 2018Review
- Inflammasome activation and assembly at a glance.Journal of cell science · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the gene encoding pyrin are associated with autoinflammatory disorder Familial Mediterranean Fever (FMF). A FMF-knock-in mouse strain that expresses chimeric pyrin protein with a V726A mutation (Mefv
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.