Evidence map›Paper›PMID 27998721›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2017

Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation.

Heather M Snyder, Tim Ahles, Stuart Calderwood, Maria C Carrillo, Honglei Chen, Chung-Chou H Chang, Suzanne Craft, Philip De Jager, Jane A Driver, Howard Fillit and 8 more

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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  17. Cognitive Effects of Cancer and Cancer Treatments.Annual review of clinical psychology · 2018
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 15 institutions in 3 countries.

Heather M SnyderDivision of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
Tim AhlesDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stuart CalderwoodRadiation Oncology, Harvard University Medical School, Boston, MA, USA.
Maria C CarrilloDivision of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA.
Honglei ChenDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
Chung-Chou H ChangDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh Medical School, Pittsburgh, PA, USA; Clinical and Translational Science, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Suzanne CraftDivision of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University of Medicine, Winston-Salem, NC, USA.
Philip De JagerGeriatric Research Education and Clinical Center, VA Boston HealthCare System, Boston, MA, USA.
Jane A DriverDivision of Aging, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard University Medical School, Boston, MA, USA.
Howard FillitScientific Affairs, Alzheimer's Drug Discovery Foundation, New York, NY, USA.
David KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Michael LotzeDepartments of Surgery, Immunology and Bioengineering, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Mary C TierneyDepartment of Family and Community Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada.
Suzana PetanceskaDivision of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Andrew SaykinDepartment of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Sudha SeshadriDivision of Neurology, Boston University Medical School, Boston, MA, USA.
Diana ShinemanScientific Affairs, Alzheimer's Drug Discovery Foundation, New York, NY, USA.
Mary GanguliProfessor of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, USA.
Alzheimer's Association · USAlzheimer's Drug Discovery Foundation · USHarvard University · USBoston University · USDepartment of Health · TWIndiana University – Purdue University Indianapolis · USMayo Clinic in Arizona · USMemorial Sloan Kettering Cancer Center · USMichigan State University · USNational Institute on Aging · USSunnybrook Health Science Centre · CAUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · USVA Boston Healthcare System · USWake Forest University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
NCI NIH HHS P30 CA008748NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG008122NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

Recent population studies suggest an intriguing inverse relationship between several types of cancer and neurodegenerative diseases, including Alzheimer's disease. Understanding the intersection of the underlying biology for these two distinct families of diseases with one another may offer novel approaches to identify new therapeutic approaches and possible opportunities to repurpose existing drug candidates. The Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened a one-day workshop to delve into this discussion. Workshop participants outlined research focus areas, potential collaborations, and partnerships for future action.

Indexed as

Alzheimer DiseaseNeoplasmsAntineoplastic AgentsDementiaDrug DiscoveryHumansAntineoplastic AgentsAlzheimer's diseaseBiological mechanismsCancerEpidemiologyGeneticsOncologyRepurpose therapy

Identifiers

PMID27998721
PMCPMC5548424
OpenAlexW2566198961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.