Evidence map›Paper›PMID 27998282›Full record

ArticleJournal of translational medicine2016

Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?

Harald A Bergan, Per S Halvorsen, Helge Skulstad, Erik Fosse, Jan F Bugge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. CPR and ECMO: The Next Frontier.Rambam Maimonides medical journal · 2020
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Harald A BerganDivision of Emergencies and Critical Care, Department of Research and Development, Oslo University Hospital, Oslo, Norway. haaber@ous-hf.no.
Per S HalvorsenThe Intervention Centre, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Helge SkulstadFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Erik FosseFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Jan F BuggeDivision of Emergencies and Critical Care, Department of Research and Development, Oslo University Hospital, Oslo, Norway.
Oslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The survival after a cardiac arrest is related to post-arrest cardiac function, and the application of therapeutic hypothermia post-arrest is hypothesized to improve cardiac outcome. The present animal study compares normothermic and hypothermic E-CPR considering resuscitation success, post-arrest left ventricular function and magnitude of myocardial injury.

methodsAfter a 15-min untreated ventricular fibrillation, the pigs (n = 20) were randomized to either normothermic (38 °C) or hypothermic (32-33 °C) E-CPR. Defibrillation terminated ventricular fibrillation after 5 min of E-CPR, and extracorporeal support continued for 2 h, followed by warming, weaning and a stabilization period. Magnetic resonance imaging and left ventricle pressure measurements were used to assess left ventricular function pre-arrest and 5 h post-arrest. Myocardial injury was estimated by serum concentrations of cardiac TroponinT and Aspartate transaminase (ASAT).

resultsE-CPR resuscitated all animals and the hypothermic strategy induced therapeutic hypothermia within minutes without impairment of the resuscitation success rate. All animals suffered a severe global systolic left ventricular dysfunction post-arrest with 50-70% reductions in stroke volume, ejection fraction, wall thickening, strain and mitral annular plane systolic excursion. Serum concentrations of cardiac TroponinT and ASAT increased considerably post-arrest. No significant differences were found between the two groups.

conclusionsTwo-hour therapeutic hypothermia during E-CPR offers an equal resuscitation success rate, but does not preserve the post-arrest cardiac function nor reduce the magnitude of myocardial injury, compared to normothermic E-CPR. Trial registration FOTS 4611/13 registered 25 October 2012.

Indexed as

Cardiopulmonary ResuscitationHypothermia, InducedAnimalsAspartate AminotransferasesBlood Gas AnalysisBlood PressureBody TemperatureCardiotonic AgentsElectric CountershockHeartHeart RateHemodynamicsMagnetic Resonance ImagingStaining and LabelingSus scrofaTroponin TAspartate AminotransferasesCardiotonic AgentsTroponin TCardiac functionCardiopulmonary resuscitationExtracorporeal circulationExtracorporeal membrane oxygenationTherapeutic hypothermia

Identifiers

PMID27998282
PMCPMC5175383
OpenAlexW2565136568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.