ArticleTissue engineering. Part A2017
Effects of Local Antibiotic Delivery from Porous Space Maintainers on Infection Clearance and Induction of an Osteogenic Membrane in an Infected Bone Defect.
Article in Tissue engineering. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Bone defect treatment: does the type and properties of the spacer affect the induction of Masquelet membrane? Evidence today.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Pooled it
- Antibiotic-Releasing Porous Shell Cements.Antibiotics (Basel, Switzerland) · 2026Article
- The masquelet technique for severe open fractures: current insights.Journal of orthopaedic surgery and research · 2026Review
- Clinical efficacy of Masquelet technique in the treatment of tibial and fibular bone defects caused by severe gunshot wounds.Frontiers in medicine · 2026Article
- Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Review
- Engineering the bone reconstruction surgery: the case of the masquelet-induced membrane technique.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Construction of a 3D Degradable PLLA/β-TCP/CS Scaffold for Establishing an Induced Membrane Inspired by the Modified Single-Stage Masquelet Technique.ACS biomaterials science & engineering · 2025Article
- Application of composite layered repair system using titanium mesh, bone cement and vacuum sealing drainage for chest wall defect.Frontiers in medicine · 2025Article
- Bone reconstruction with modified Masquelet technique in open distal femoral fractures: a case series.BMC musculoskeletal disorders · 2024Article
- Comparative bone healing with induced membrane technique (IMT) versus empty defects in septic and aseptic conditions in a novel rabbit humerus model.BMC musculoskeletal disorders · 2023Article
- Choosing the right animal model for osteomyelitis research: Considerations and challenges.Journal of orthopaedic translation · 2023Review
- [Biological reconstruction of large bone defects : Masquelet technique and new procedures].Unfallchirurgie (Heidelberg, Germany) · 2023Review
- Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps.PloS one · 2023Article
- Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration.Materials today. Bio · 2022Review
- Reconstruction of a tibial diaphyseal bone defect using the Masquelet technique. A case report.Trauma case reports · 2022Article
- Review
- Surgical Classification for Preclinical Rat Femoral Bone Defect Model: Standardization Based on Systematic Review, Anatomical Analysis and Virtual Surgery.Bioengineering (Basel, Switzerland) · 2022Review
- Masquelet technique in military practice: specificities and future directions for combat-related bone defect reconstruction.Military Medical Research · 2022Review
- Effects of PMMA spacer loaded with varying vancomycin concentrations on bone regeneration in the Masquelet technique.Scientific reports · 2022Article
- The induced membrane technique in animal models: a systematic review.OTA international : the open access journal of orthopaedic trauma · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Reconstruction of large bone defects can be complicated by the presence of both infection and local antibiotic administration. This can be addressed through a two-stage reconstructive approach, called the Masquelet technique, that involves the generation of an induced osteogenic membrane over a temporary poly(methyl methacrylate) (PMMA) space maintainer, followed by definitive reconstruction after the induced membrane is formed. Given that infection and antibiotic delivery each have independent effects on local tissue response, the objective of this study is to evaluate the interaction between local clindamycin release and bacterial contamination with regards to infection prevention and the restoration of pro-osteogenic gene expression in the induced membrane. Porous PMMA space maintainers with or without clindamycin were implanted in an 8 mm rat femoral defect model with or without Staphylococcus aureus inoculation for 28 days in a full-factorial study design (four groups, n = 8/group). Culture results demonstrated that 8/8 animals in the inoculated/no antibiotic group were infected at 4 weeks, which was significantly reduced to 1/8 animals in the inoculated/antibiotic group. Quantitative polymerase chain reaction analysis demonstrated that clindamycin treatment restores inflammatory cytokine and growth factor expression to the same levels as the no inoculation/no antibiotic group, demonstrating that clindamycin can ameliorate the negative effects of bacterial inoculation and does not itself negatively impact the expression of important cytokines. Main effect analysis shows that bacterial inoculation and clindamycin treatment have independent and interacting effects on the gene expression profile of the induced membrane, further highlighting that antibiotics play an important role in the regeneration of infected defects apart from their antimicrobial properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.