ArticleOral diseases2017
Elucidating the role of hyposalivation and autoimmunity in oral candidiasis.
Article in Oral diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular Insights into Oral Manifestations in Sjögren's Disease.International journal of molecular sciences · 2026Review
- Oral manifestations in patients with chronic hepatitis C.BMC oral health · 2025Observational
- Oral viral, fungal, and bacterial infections linked to comorbidities: A case series from a Brazilian referral center.Journal of clinical and experimental dentistry · 2025Article
- Article
- Clinical features and risk factors for Sjogren's syndrome patients suffering from oral candidiasis in Shanxi, China.BMC oral health · 2024Article
- Oral Findings, Salivary Copper, Magnesium, and Leptin in Type II Diabetic Patients in Relation to OralInternational journal of microbiology · 2024Article
- Immunoglobulin Disorders and the Oral Cavity: A Narrative Review.Journal of clinical medicine · 2022Review
- Periodontal Disease: The Good, The Bad, and The Unknown.Frontiers in cellular and infection microbiology · 2021Review
- Galectin-3, Possible Role in Pathogenesis of Periodontal Diseases and Potential Therapeutic Target.Frontiers in pharmacology · 2021Review
- Docking Prediction, Antifungal Activity, Anti-Biofilm Effects onMolecules (Basel, Switzerland) · 2020Article
- Risk factors related to oral candidiasis in patients with primary Sjögren's syndrome.Medicina oral, patologia oral y cirugia bucal · 2020Article
- Integrated Analysis of Clinical and Microbiome Risk Factors Associated with the Development of Oral Candidiasis during Cancer Chemotherapy.Journal of fungi (Basel, Switzerland) · 2019Article
- Evaluating All Potential Oral Complications of Diabetes Mellitus.Frontiers in endocrinology · 2019Review
- Tissue-Specific Immunity at the Oral Mucosal Barrier.Trends in immunology · 2018Review
- Comparative evaluation of fluconazole and clotrimazole in treatment of oral candidiasis.Journal of oral and maxillofacial pathology : JOMFPArticle
- Hyposalivation and oral candidiasis-A short review.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionOral candidiasis (OC) is a potential oral complication in Sjögren's syndrome (SS). Some studies indicate that the low stimulated salivary flow and not low unstimulated salivary flow is associated with OC in SS, while others report that the underlying autoimmune disorders contribute to OC, based solely on correlation coefficients. Given the conflicting and limited existing evidence, we purposed to ascertain the role of both salivary gland dysfunction (hyposalivation based on unstimulated and stimulated flow rates) and autoimmunity (SS, other autoimmune disorders) in OC among those with SS, other salivary gland dysfunction, and non-salivary gland dysfunction controls (NSGD).
methodsA nested case-control study was designed within a larger NIH/NIDCR cohort. Descriptive analyses, nonparametric tests, comparative analyses, and multivariate logistic regression analyses were undertaken.
resultsData on 1526 subjects (701 SS, 247 ISS, 355 Sicca, and 223 NSGD) were obtained from the source cohort of 2046 and analyzed for this study. The median whole unstimulated salivary flow rate (WUS, ml 15 min
conclusionSalivary gland dysfunction (hyposalivation with WUS being a stronger predictor than TSS) and autoimmunity (SS, other autoimmune disorders, medications, i.e., DMARDS) are both independent predictors of OC. Diabetes mellitus is an independent predictor of OC among those with salivary gland dysfunction. Our findings suggest that these independent predictors should be considered in the prevention and management of OC in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.