Evidence map›Paper›PMID 27997839›Full record

ArticleCurrent biology : CB2016

Phagocytosis: How Macrophages Tune Their Non-professional Counterparts.

Spencer A Freeman, Sergio Grinstein

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Differential engulfment ofEXCLI journal · 2020
    Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Spencer A FreemanProgram in Cell Biology, Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada.
Sergio GrinsteinProgram in Cell Biology, Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, 290 Victoria Street, Toronto, Ontario, M5C 1N8, Canada. Electronic address: sergio.grinstein@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foreign particles and apoptotic cells are engulfed by professional phagocytes (e.g. macrophages) and non-professional phagocytes (e.g. epithelial cells). These phagocyte populations exchange information to coordinate and prioritise their activities, but the nature of these messages was unknown. Recently, IGF-1 and microvesicles were identified as means of communication between macrophages and epithelia.

Indexed as

AnimalsCell CommunicationCell-Derived MicroparticlesEpithelial CellsInflammationInsulin-Like Growth Factor IMacrophagesMammalsPhagocytosisInsulin-Like Growth Factor I

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.