ArticleDevelopmental cell2016
Generic Theoretical Models to Predict Division Patterns of Cleaving Embryos.
Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Marine Model Organisms for Mechanobiology Studies.Results and problems in cell differentiation · 2026Review
- Manipulation of Spindle Position Using Magnetic Tweezers in Sea Urchin Embryos.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Manipulation of Embryonic Cleavage Geometry Using Magnetic Tweezers.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Quantitative models for building and growing fated small cell networks.Interface focus · 2022Review
- The extra-embryonic space and the local contour are crucial geometric constraints regulating cell arrangement.Development (Cambridge, England) · 2022Article
- Combined effect of cell geometry and polarity domains determines the orientation of unequal division.eLife · 2021Article
- Roadmap for the multiscale coupling of biochemical and mechanical signals during development.Physical biology · 2021Review
- Physical constraints on early blastomere packings.PLoS computational biology · 2021Article
- Article
- Organelle size scaling over embryonic development.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos.Developmental cell · 2020Article
- Cytoskeleton Force Exertion in Bulk Cytoplasm.Frontiers in cell and developmental biology · 2020Review
- A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst.Developmental cell · 2019Article
- Cell shape and intercellular adhesion regulate mitotic spindle orientation.Molecular biology of the cell · 2019Article
- Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins.Nature communications · 2019Article
- Self-Similar Dynamics of Nuclear Packing in the Early Drosophila Embryo.Biophysical journal · 2019Article
- Asymmetric division through a reduction of microtubule centering forces.The Journal of cell biology · 2019Article
- Predicting Division Planes of Three-Dimensional Cells by Soap-Film Minimization.The Plant cell · 2018Article
- Combinatorial Contact Cues Specify Cell Division Orientation by Directing Cortical Myosin Flows.Developmental cell · 2018Article
- Physical Forces Determining the Persistency and Centering Precision of Microtubule Asters.Nature physics · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Life for all animals starts with a precise 3D choreography of reductive divisions of the fertilized egg, known as cleavage patterns. These patterns exhibit conserved geometrical features and striking interspecies invariance within certain animal classes. To identify the generic rules that may govern these morphogenetic events, we developed a 3D-modeling framework that iteratively infers blastomere division positions and orientations, and consequent multicellular arrangements. From a minimal set of parameters, our model predicts detailed features of cleavage patterns in the embryos of fishes, amphibians, echinoderms, and ascidians, as well as the genetic and physical perturbations that alter these patterns. This framework demonstrates that a geometrical system based on length-dependent microtubule forces that probe blastomere shape and yolk gradients, biased by cortical polarity domains, may dictate division patterns and overall embryo morphogenesis. These studies thus unravel the default self-organization rules governing early embryogenesis and how they are altered by deterministic regulatory layers.
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Registered trials
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