ArticleJournal of cellular and molecular medicine2017
Inhibition of platelet aggregation and thrombosis by indole alkaloids isolated from the edible insect Protaetia brevitarsis seulensis (Kolbe).
Article in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Optimization of Bioactive Polysaccharide Extraction fromACS omega · 2026Article
- Isolation and Quantification of L-Tryptophan fromInsects · 2025Article
- Antitumor Activity of Tetrahydro-β-carboline Derivatives via Inhibition of Kinesin Spindle Protein: Validation by Molecular Docking, Molecular Dynamics, and In Vitro Assays.International journal of molecular sciences · 2025Article
- Impact of Edible Insect Polysaccharides on Mouse Gut Microbiota: A Study on White-Spotted Flower Chafer Larva (Foods (Basel, Switzerland) · 2024Article
- Comparative Analysis of Hindgut Microbiota Variation inMicroorganisms · 2024Article
- Human and gut microbiota synergy in a metabolically active superorganism: a cardiovascular perspective.Frontiers in cardiovascular medicine · 2024Review
- Chondroprotective effects ofFood science & nutrition · 2023Article
- The Inhibitory Effects ofPreventive nutrition and food science · 2023Article
- Insects as food and medicine: a sustainable solution for global health and environmental challenges.Frontiers in nutrition · 2023Review
- Innovation in Alternative Food Sources: A Review of a Technological State-of-the-Art of Insects in Food Products.Foods (Basel, Switzerland) · 2022Review
- Pharmacological Actions of 5-Hydroxyindolin-2 on Modulation of Platelet Functions and Thrombus Formation via Thromboxane AInternational journal of molecular sciences · 2022Article
- Microflora for improving theiScience · 2022Article
- Characterization of Microorganisms fromMicroorganisms · 2022Article
- 16S rRNA Gene Sequencing Reveals Specific Gut Microbes Common to Medicinal Insects.Frontiers in microbiology · 2022Article
- Evolution of the quality of prenatal care in the primary network of Brazil from 2012 to 2018: What can (and should) improve?PloS one · 2022Article
- Identification and field verification of an aggregation pheromone from the white-spotted flower chafer, Protaetia brevitarsis Lewis (Coleoptera: Scarabaeidae).Scientific reports · 2021Article
- Effects of larval extracts from identifiedFood science & nutrition · 2021Article
- Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine.Biomolecules & therapeutics · 2021Review
- Neuroprotective Effect ofInternational journal of molecular sciences · 2021Article
- Article
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6 authors.
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Abstract
Protaetia brevitarsis seulensis (Kolbe) has been temporarily registered as a food material by the Ministry of Food and Drug Safety of Korea (MFDS). The current study aimed to discover small antithrombotic molecules from this edible insect. Five indole alkaloids, 5-hydroxyindolin-2-one (1), (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (2), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3), (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (4) and L-tryptophan (5), were isolated from the insect. Among them, compounds 1 and 2 prolonged aPTT and PT and impaired thrombin and FXa generation on HUVEC surface. Moreover, these compounds inhibited platelet aggregation. Antithrombotic effects of compounds 1 and 2 were further confirmed in pre-clinical models of pulmonary embolism and arterial thrombosis. Collectively, these results demonstrated that compounds 1 and 2 could be effective antithrombotic agents and serve as new scaffolds for the development of antithrombotic drug.
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