Trial reportPloS one2016
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Contemporary Challenges in Venous Thromboembolism: Evolving Populations and Implications for Management and Risk Stratification.Journal of clinical medicine · 2026Review
- Combined Effect of Hemoglobin Levels and Obesity on the Risk of Incident Venous Thromboembolism: The Tromsø Study.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Acute Deep Vein Thrombosis in the Setting of Tirzepatide Use: A Case Highlighting Emerging Concerns.JCEM case reports · 2025Article
- The Interplay Between Obesity and Venous Thromboembolism: From Molecular Aspects to Clinical Issue.International journal of molecular sciences · 2025Review
- Frailty and risk of venous thromboembolism in older adults: the Atherosclerosis Risk in Communities Study.Journal of thrombosis and haemostasis : JTH · 2025Article
- Mapping the effectiveness and risks of GLP-1 receptor agonists.Nature medicine · 2025 · on this mapArticle
- Venous thrombosis and obesity: from clinical needs to therapeutic challenges.Internal and emergency medicine · 2025Review
- A retrospective observational study on case reports of adverse drug reactions (ADRs) to tirzepatide.Frontiers in pharmacology · 2025Article
- Venous Thromboembolism and Obesity: Moving Toward a Better Understanding of the Population-Attributable Risk.Thrombosis and haemostasis · 2024Article
- Epidemiology and prevention of venous thromboembolism.Nature reviews. Cardiology · 2023Review
- Incidence and risk factors for venous thromboembolism in patients with ovarian cancer during neoadjuvant chemotherapy: a meta-analysis.American journal of cancer research · 2023Article
- Fertility, pregnancy and post partum management after bariatric surgery: a narrative review.The Medical journal of Australia · 2022Review
- Weight Change and Mortality from Cardiovascular Diseases: The Japan Collaborative Cohort Study.Journal of atherosclerosis and thrombosis · 2021Article
- Incidence of Deep Vein Thrombosis and Its Effect on Health-Related Quality of Life Among Nurses of Greek Public Hospitals: A Multicenter Study.Advances in experimental medicine and biology · 2021Article
- Exploring Opportunities for Primary Prevention of Unprovoked Venous Thromboembolism: Ready for Prime Time?Journal of the American Heart Association · 2020Review
- Association of Preoperative Body Weight and Weight Loss With Risk of Death After Bariatric Surgery.JAMA network open · 2020Article
- Changes in Childhood Body-Mass Index and Risk of Venous Thromboembolism in Adulthood.Journal of the American Heart Association · 2019Article
- Adiposity throughout the life course and risk of venous thromboembolism.Thrombosis research · 2018Article
- Extensive Deep Vein Thrombosis in a Young Man Taking Tirzepatide for Weight Loss.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a major risk factor for venous thromboembolism (VTE), but it is unknown to what extent weight change over time affects VTE risk.
aimsTo investigate the association between weight change and risk of incident VTE in a population-based cohort with repeated measurements.
methodsParticipant data were collected from the Tromsø 3 (1986-87), 4 (1994-95), 5 (2000-01) and 6 (2007-08) surveys. Subjects who attended two subsequent or more surveys were included (n = 17802), and weight change between the surveys was calculated. Person-time at risk was accrued from the second of two subsequent vists until the next survey, the date of an incident VTE, migration, death or study end (December 31st 2012), whichever came first. Cox regression models were used to calculate risk of VTE according to change in body weight.
resultsThere were 302 incident VTE events during a median of 6.0 years of follow-up. Subjects who gained most weight (7.5-40.0 kg weight gain) had a 1.9-fold higher risk of VTE compared to those with no or a moderate (0-7.4 kg) weight gain (HR 1.92; 95% CI 1.38-2.68). The VTE risk by ≥7.5 kgs over no or moderate (0-7.4 kg) weight gain was highest (HR 3.75; 95% 1.83-7.68) in subjects with baseline body mass index (BMI) ≥30 kg/m2. There was a joint effect of weight gain and baseline BMI on VTE risk. Those with BMI ≥30 who gained ≥7.5 kgs had a 6.6-fold increased risk (HR 6.64; 95% CI 3.61-12.22) compared to subjects with BMI <25 and no or moderate (0-7.4 kg) weight gain.
conclusionsOur findings imply that further weight gain is a considerable risk factor for VTE, particularly in obese individuals.
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