ArticlePloS one2016
In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- From Simulation to Therapy: Light Guidance Through Zirconium Dental Implants for Bone-Targeted Photodynamic Inactivation.Bioengineering (Basel, Switzerland) · 2026Article
- Design and characterisation of intervertebral disc mimicking phantoms for photoacoustic imaging.Photoacoustics · 2026Article
- Light transport in the human spine for optical bone density assessment: Monte Carlo modeling and validation.Biomedical optics express · 2025Article
- Broadband time domain diffuse optical characterization of human cadaver bone from 500 to 1100 nm.Scientific reports · 2025Article
- Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring.Neurophotonics · 2025Article
- Assessment of power spectral density of microvascular hemodynamics in skeletal muscles at very low and low-frequency via near-infrared diffuse optical spectroscopies.Biomedical optics express · 2023Article
- Co-registered speckle contrast optical tomography and frequency domain-diffuse optical tomography for imaging of the fifth metatarsal.Biomedical optics express · 2022Article
- Cherenkov light emission in molecular radiation therapy of the thyroid and its application to dosimetry.Biomedical optics express · 2022Article
- Perspective on the integration of optical sensing into orthopedic surgical devices.Journal of biomedical optics · 2022Article
- Mechanisms of bone blood flow regulation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Article
- Characterization of bony anatomic regions in pediatric and adult healthy volunteers using diffuse optical spectroscopic imaging.Journal of biomedical optics · 2020Article
- Non-invasive investigation of adipose tissue by time domain diffuse optical spectroscopy.Biomedical optics express · 2020Article
- Optical characterization of porcine tissues from various organs in the 650-1100 nm range using time-domain diffuse spectroscopy.Biomedical optics express · 2020Article
- The Case for Measuring Long Bone Hemodynamics With Near-Infrared Spectroscopy.Frontiers in physiology · 2020Review
- Near infrared spectroscopy for measuring changes in bone hemoglobin content after exercise in individuals with spinal cord injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges.Sensors (Basel, Switzerland) · 2017Review
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care.
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