ArticlePLoS biology2016
Suppression of Dopamine Neurons Mediates Reward.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Article
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- Article
- Hyperdopaminergic States Bias Explorations-Exploitation Trade-Off in Foraging and Impair Survival.The European journal of neuroscience · 2026Article
- Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila.Biomedical journal · 2026Article
- Article
- Re-exposure to reward re-evaluates related memories.Current biology : CB · 2026Article
- Article
- Dual roles ofiScience · 2025Article
- Review
- Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.eLife · 2025Article
- Arsenic toxicity in theFrontiers in toxicology · 2025Article
- Review
- Article
- The caloric value of food intake structurally adjusts a neuronal mushroom body circuit mediating olfactory learning inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Dual roles of dopaminergic pathways in olfactory learning and memory in the oriental fruit fly, Bactrocera dorsalis.Pesticide biochemistry and physiology · 2024Article
- Article
- Article
- Independent insulin signaling modulators govern hot avoidance under different feeding states.PLoS biology · 2023Article
- A rapid and bidirectional reporter of neural activity reveals neural correlates of social behaviors in Drosophila.Nature neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massive activation of dopamine neurons is critical for natural reward and drug abuse. In contrast, the significance of their spontaneous activity remains elusive. In Drosophila melanogaster, depolarization of the protocerebral anterior medial (PAM) cluster dopamine neurons en masse signals reward to the mushroom body (MB) and drives appetitive memory. Focusing on the functional heterogeneity of PAM cluster neurons, we identified that a single class of PAM neurons, PAM-γ3, mediates sugar reward by suppressing their own activity. PAM-γ3 is selectively required for appetitive olfactory learning, while activation of these neurons in turn induces aversive memory. Ongoing activity of PAM-γ3 gets suppressed upon sugar ingestion. Strikingly, transient inactivation of basal PAM-γ3 activity can substitute for reward and induces appetitive memory. Furthermore, we identified the satiety-signaling neuropeptide Allatostatin A (AstA) as a key mediator that conveys inhibitory input onto PAM-γ3. Our results suggest the significance of basal dopamine release in reward signaling and reveal a circuit mechanism for negative regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.