Evidence map›Paper›PMID 27997529›Full record

ArticlePediatric research2017

Renal dysfunction in early adulthood following birth asphyxia in male spiny mice, and its amelioration by maternal creatine supplementation during pregnancy.

Stacey J Ellery, Domenic A LaRosa, Luise A Cullen-McEwen, Russell D Brown, Rod J Snow, David W Walker, Michelle M Kett, Hayley Dickinson

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause.Journal of the International Society of Sports Nutrition · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Article
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Stacey J ElleryThe Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics & Gynaecology, Monash Medical Centre, Monash University, Melbourne, Australia.
Domenic A LaRosaThe Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics & Gynaecology, Monash Medical Centre, Monash University, Melbourne, Australia.
Luise A Cullen-McEwenDepartment of Anatomy and Developmental Biology, Monash University, Clayton Campus, Melbourne, Australia.
Russell D BrownDepartment of Physiology, Monash University, Clayton Campus, Melbourne, Victoria, Australia.
Rod J SnowInstitute for Physical Activity and Nutrition, Deakin University, Burwood Campus, Melbourne, Australia.
David W WalkerThe Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics & Gynaecology, Monash Medical Centre, Monash University, Melbourne, Australia.
Michelle M KettDepartment of Physiology, Monash University, Clayton Campus, Melbourne, Victoria, Australia.
Hayley DickinsonThe Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics & Gynaecology, Monash Medical Centre, Monash University, Melbourne, Australia.
Monash University · AUMonash Medical Centre · AUDeakin University · AUMonash Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury affects ~70% of asphyxiated newborns, and increases their risk of developing chronic kidney disease later in life. Acute kidney injury is driven by renal oxygen deprivation during asphyxia, thus we hypothesized that creatine administered antenatally would protect the kidney from the long-term effects of birth asphyxia.

methodsPregnant spiny mice were fed standard chow or chow supplemented with 5% creatine from 20-d gestation (midgestation). One day prior to term (37-d gestation), pups were delivered by caesarean or subjected to intrauterine asphyxia. Litters were allocated to one of two time-points. Kidneys were collected at 1 mo of age to estimate nephron number (stereology). Renal function (excretory profile and glomerular filtration rate) was measured at 3 mo of age, and kidneys then collected for assessment of glomerulosclerosis.

resultsCompared with controls, at 1 mo of age male (but not female) birth-asphyxia offspring had 20% fewer nephrons (P < 0.05). At 3 mo of age male birth-asphyxia offspring had 31% lower glomerular filtration rate (P < 0.05) and greater glomerular collagen IV content (P < 0.01). Antenatal creatine prevented these renal injuries arising from birth asphyxia.

conclusionMaternal creatine supplementation during pregnancy may be an effective prophylactic to prevent birth asphyxia induced acute kidney injury and the emergence of chronic kidney disease.

Indexed as

Maternal Nutritional Physiological PhenomenaAcute Kidney InjuryAnimalsAnimals, NewbornAsphyxia NeonatorumCollagen Type IVCreatineDietary SupplementsFemaleKidneyKidney Failure, ChronicKidney GlomerulusMaleMiceNephronsOrgan SizeCollagen Type IVCreatineOxygen

Identifiers

PMID27997529
OpenAlexW2564711365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.