Evidence map›Paper›PMID 27997361›Full record

ArticleAging2016

Association of neovascular age-related macular degeneration with month and season of birth in Italy.

Antonio Longo, Alessandra Casuccio, Luca Pani, Teresio Avitabile, Salvatore Cillino, Maurizio G Uva, Vincenza Bonfiglio, Andrea Russo, Guglielmo Parisi, Gilda Cennamo and 4 more

Open access · greenAbstract read
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Antonio LongoAzienda Policlinico-Vittorio Emanuele, Catania, Italy.
Alessandra CasuccioDepartments of Sciences for Health Promotion and Mother Child Care, University of Palermo, Palermo, Italy.
Luca PaniItalian Medicines Agency, Rome, Italy.
Teresio AvitabileAzienda Policlinico-Vittorio Emanuele, Catania, Italy.
Salvatore CillinoEye Clinic, University of Palermo, Palermo, Italy.
Maurizio G UvaAzienda Policlinico-Vittorio Emanuele, Catania, Italy.
Vincenza BonfiglioAzienda Policlinico-Vittorio Emanuele, Catania, Italy.
Andrea RussoAzienda Policlinico-Vittorio Emanuele, Catania, Italy.
Guglielmo ParisiAzienda Policlinico-Vittorio Emanuele, Catania, Italy.
Gilda CennamoEye Clinic, University of Naples Federico II, Naples, Italy.
Claudio FurinoEye Clinic, University of Bari, Bari, Italy.
Mariacristina ParravanoFondazione G.B. Bietti, IRCCS, Rome, Italy.
Entela XoxiItalian Medicines Agency, Rome, Italy.
Michele ReibaldiAzienda Policlinico-Vittorio Emanuele, Catania, Italy.
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele · ITItalian Medicines Agency · ITUniversity of Palermo · ITFondazione G.B. Bietti · ITUniversity of Bari Aldo Moro · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to investigate the influence of season and month of birth on the risk of neovascular age-related macular degeneration (n-AMD) in Italy, we evaluated the month birth and sex of all patients, recorded in the anti-vascular endothelial growth factor (VEGF) monitoring registry of the Italian Medicines Agency, born between 1925-1944, who received intravitreal anti-VEGF injections for n-AMD between January 1, 2013 and July 29, 2015. The numbers of all births in Italy in the same years, extracted from the Italian National Institute of Statistics, were used to calculate the expected number of n-AMD cases. Overall, 45,845 patients (19,207 men, 26,638 women) received intravitreal anti-VEGF for n-AMD; in the same years, 20,140,426 people (10,334,262 male, 9,806,164 female) were born in Italy. Comparing the observed number of n-AMD cases with the expected number of n- AMD cases in each season, we found that the season-specific risk for n-AMD was 2.5% higher for those born in summer (OR=1.03, Bonferroni-corrected

Indexed as

SeasonsAgedAged, 80 and overAngiogenesis InhibitorsAptamers, NucleotideBevacizumabFemaleHumansIncidenceItalyMacular DegenerationMaleNeovascularization, PathologicRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsafliberceptAngiogenesis InhibitorsAptamers, NucleotideBevacizumabpegaptanibRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsVascular Endothelial Growth Factor Aanti-VEGFmonth of birthneovascular age-related macular degenerationneovascular AMDseason of birth

Identifiers

PMID27997361
PMCPMC5310660
OpenAlexW2564394333

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.