Evidence map›Paper›PMID 27997339›Full record

ArticleVaccine2016

Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV.

Ethan Poteet, Phoebe Lewis, Changyi Chen, Sam On Ho, Thai Do, SuMing Chiang, Celia Labranche, David Montefiori, Gary Fujii, Qizhi Yao

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Noninvasive vaccination against infectious diseases.Human vaccines & immunotherapeutics · 2018
    Review
  13. Article
  14. Viruses Seen by Our Cells: The Role of Viral RNA Sensors.Journal of immunology research · 2018
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ethan PoteetMichael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX 77030, USA.
Phoebe LewisMichael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX 77030, USA.
Changyi ChenMichael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX 77030, USA.
Sam On HoMolecular Express, Inc., Rancho Domínguez, CA 90220, USA.
Thai DoMolecular Express, Inc., Rancho Domínguez, CA 90220, USA.
SuMing ChiangMolecular Express, Inc., Rancho Domínguez, CA 90220, USA.
Celia LabrancheDepartment of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
David MontefioriDepartment of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Gary FujiiMolecular Express, Inc., Rancho Domínguez, CA 90220, USA.
Qizhi YaoMichael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX 77030, USA; Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. Electronic address: qizhiyao@bcm.edu.
Baylor College of Medicine · USDuke Medical Center · USDuke University Hospital · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
Novel VLP Adjuvant based on the VesiVax systemR43AI104073 · NIAID · MOLECULAR EXPRESS, INC. · PI FUJII, GARY · 2013 to 2014
$600k
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
BLRD VA I01 BX001474NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIAID NIH HHS R43 AI104073NIGMS NIH HHS R25 GM056929
6 · The paper itself

Abstract

Human Immunodeficiency Virus (HIV) Virus-Like Particles (VLPs) composed of HIV

Indexed as

Adjuvants, ImmunologicImmunity, HumoralAIDS VaccinesAnimalsAntibodies, NeutralizingGene Products, gagGerminal CenterHIV-1HIV AntibodiesHIV InfectionsLigandsMiceMice, Inbred C57BLT-Lymphocytes, CytotoxicToll-Like Receptor 3Vaccines, SyntheticAdjuvants, ImmunologicAIDS VaccinesAntibodies, NeutralizingGene Products, gagHIV AntibodiesLigandsToll-Like Receptor 3Vaccines, SyntheticVaccines, Virus-Like ParticleGerminal centerHIVNeutralizing antibodyTLR3VaccineVirus Like Particle (VLP)

Identifiers

PMID27997339
PMCPMC8370845
OpenAlexW2539520145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.