ArticleEnvironmental science & technology2017
Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure.
Article in Environmental science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Prenatal Exposure to Potentially Toxic Metals and Their Effects on Genetic Material in Offspring: a Systematic Review.Biological trace element research · 2023Pooled it
- Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial.Environmental science & technology · 2025Trial
- Arsenic exposure, arsenic metabolism, and plasma lipidome in relation to type 2 diabetes and glycemic traits: a lipidome-wide association study.Journal of advanced research · 2026Article
- Integrating omics and artificial intelligence in pediatric environmental health: tools, challenges, and cohort-based insights.Pediatric research · 2026Review
- Oxidative Stress-Related Metabolomic Alterations in Pregnancy: Evidence from Exposure to Air Pollution, Metals/Metalloid, and Tobacco Smoke.Antioxidants (Basel, Switzerland) · 2025Review
- Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.Exposure and health · 2022Article
- A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort.Environment international · 2022Article
- Early Cardiovascular Risk in E-cigarette Users: the Potential Role of Metals.Current environmental health reports · 2020Review
- Health effects of arsenic exposure in Latin America: An overview of the past eight years of research.The Science of the total environment · 2020Article
- Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.BioMed research international · 2019Article
- Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures.Current environmental health reports · 2018Review
- Toxic metals in amniotic fluid and altered gene expression in cell-free fetal RNA.Prenatal diagnosis · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Prenatal inorganic arsenic (iAs) exposure is associated with health effects evident at birth and later in life. An understanding of the relationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal critical molecular modifications, potentially underpinning disease etiologies. In this study, nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis was used to identify metabolites in neonate cord serum associated with prenatal iAs exposure in participants from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort, in Gómez Palacio, Mexico. Through multivariable linear regression, ten cord serum metabolites were identified as significantly associated with total urinary iAs and/or iAs metabolites, measured as %iAs, %monomethylated arsenicals (MMAs), and %dimethylated arsenicals (DMAs). A total of 17 metabolites were identified as significantly associated with total iAs and/or iAs metabolites in cord serum. These metabolites are indicative of changes in important biochemical pathways such as vitamin metabolism, the citric acid (TCA) cycle, and amino acid metabolism. These data highlight that maternal biotransformation of iAs and neonatal levels of iAs and its metabolites are associated with differences in neonate cord metabolomic profiles. The results demonstrate the potential utility of metabolites as biomarkers/indicators of in utero environmental exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.